ID J0RY71_9EURY Unreviewed; 294 AA.
AC J0RY71;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Formylmethanofuran--tetrahydromethanopterin formyltransferase {ECO:0000256|HAMAP-Rule:MF_00579};
DE Short=Ftr {ECO:0000256|HAMAP-Rule:MF_00579};
DE EC=2.3.1.101 {ECO:0000256|HAMAP-Rule:MF_00579};
DE AltName: Full=H4MPT formyltransferase {ECO:0000256|HAMAP-Rule:MF_00579};
GN Name=ftr {ECO:0000256|HAMAP-Rule:MF_00579};
GN ORFNames=Metli_0513 {ECO:0000313|EMBL:EJG06481.1};
OS Methanofollis liminatans DSM 4140.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanomicrobiaceae; Methanofollis.
OX NCBI_TaxID=28892 {ECO:0000313|EMBL:EJG06481.1};
RN [1] {ECO:0000313|EMBL:EJG06481.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 4140 {ECO:0000313|EMBL:EJG06481.1};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Han J., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L.,
RA Kyrpides N., Mavromatis K., Ivanova N., Mikhailova N., Lu M., Detter J.C.,
RA Tapia R., Han C., Land M., Hauser L., Markowitz V., Cheng J.-F.,
RA Hugenholtz P., Woyke T., Wu D., Spring S., Schuler E., Brambilla E.,
RA Klenk H.-P., Eisen J.A.;
RT "The complete genome of Methanofollis liminatans DSM 4140.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the reversible transfer of a formyl group from
CC formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to
CC produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and
CC methanofuran (MFR). {ECO:0000256|HAMAP-Rule:MF_00579}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran
CC = methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin;
CC Xref=Rhea:RHEA:18061, ChEBI:CHEBI:15378, ChEBI:CHEBI:57727,
CC ChEBI:CHEBI:58018, ChEBI:CHEBI:58103, ChEBI:CHEBI:58151;
CC EC=2.3.1.101; Evidence={ECO:0000256|HAMAP-Rule:MF_00579};
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 2/3.
CC {ECO:0000256|HAMAP-Rule:MF_00579}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00579}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00579}.
CC -!- SIMILARITY: Belongs to the FTR family. {ECO:0000256|ARBA:ARBA00006770,
CC ECO:0000256|HAMAP-Rule:MF_00579}.
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DR EMBL; CM001555; EJG06481.1; -; Genomic_DNA.
DR RefSeq; WP_004037757.1; NZ_CM001555.1.
DR AlphaFoldDB; J0RY71; -.
DR STRING; 28892.Metli_0513; -.
DR PATRIC; fig|28892.9.peg.548; -.
DR HOGENOM; CLU_081314_0_0_2; -.
DR OrthoDB; 81373at2157; -.
DR UniPathway; UPA00640; UER00693.
DR Proteomes; UP000005095; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030270; F:formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.520; -; 2.
DR HAMAP; MF_00579; FTR; 1.
DR InterPro; IPR014053; ForMFR_H4MPT_ForTrfase.
DR InterPro; IPR002770; ForMFR_H4MPT_ForTrfase_C.
DR InterPro; IPR023447; ForMFR_H4MPT_ForTrfase_fd-like.
DR InterPro; IPR022667; ForMFR_H4MPT_ForTrfase_N.
DR NCBIfam; TIGR03119; one_C_fhcD; 1.
DR Pfam; PF01913; FTR; 1.
DR Pfam; PF02741; FTR_C; 1.
DR PIRSF; PIRSF006414; Ftr_formyl_trnsf; 1.
DR SUPFAM; SSF55112; Formylmethanofuran:tetrahydromethanopterin formyltransferase; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|HAMAP-Rule:MF_00579};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00579};
KW Methanogenesis {ECO:0000256|HAMAP-Rule:MF_00579};
KW One-carbon metabolism {ECO:0000256|HAMAP-Rule:MF_00579};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_00579}.
FT DOMAIN 1..141
FT /note="Formylmethanofuran: tetrahydromethanopterin
FT formyltransferase Ftr N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01913"
FT DOMAIN 144..293
FT /note="Formylmethanofuran: tetrahydromethanopterin
FT formyltransferase Ftr C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02741"
SQ SEQUENCE 294 AA; 31192 MW; 12EB3F4C59519DF9 CRC64;
MEYNGVTIDD EYAEAFPTWV SRIIITAVTE DWAYRAANEA TGFATSAIGC PCEAGIEGFL
SGDETPDGRP GVAILICAGK KKLKEQVVER LAECVLTAPT TAVFDGLPEA EERIAVKLHF
FGDGYEYQKE VGGRKCWAIP IMNGEYVGEE DFGIVKGVAG GNFFVMGENQ MAALMGAQAA
VDAIAGVGGV ITSFPGGIVA SGSKVGSKKY KFMPASTNEK YCPTLREKVE DTKVPEGVKA
IYEIVIDGLD EDCVKEAMAE GVRAACMVPG VVFISAGNFG GNLGPFKFNL ADLF
//
