ID J1Z397_9NOCA Unreviewed; 512 AA.
AC J1Z397;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=3-oxosteroid 1-dehydrogenase {ECO:0000313|EMBL:EJI95250.1};
GN ORFNames=JVH1_7440 {ECO:0000313|EMBL:EJI95250.1};
OS Rhodococcus sp. JVH1.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus.
OX NCBI_TaxID=745408 {ECO:0000313|EMBL:EJI95250.1, ECO:0000313|Proteomes:UP000009024};
RN [1] {ECO:0000313|EMBL:EJI95250.1, ECO:0000313|Proteomes:UP000009024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JVH1 {ECO:0000313|EMBL:EJI95250.1,
RC ECO:0000313|Proteomes:UP000009024};
RX PubMed=22965106; DOI=10.1128/JB.01066-12;
RA Brooks S.L., Van Hamme J.D.;
RT "Whole-Genome Shotgun Sequence of Rhodococcus Species Strain JVH1.";
RL J. Bacteriol. 194:5492-5493(2012).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJI95250.1}.
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DR EMBL; AKKP01000107; EJI95250.1; -; Genomic_DNA.
DR RefSeq; WP_009479060.1; NZ_AKKP01000107.1.
DR AlphaFoldDB; J1Z397; -.
DR PATRIC; fig|745408.3.peg.7053; -.
DR Proteomes; UP000009024; Unassembled WGS sequence.
DR GO; GO:0033765; F:steroid dehydrogenase activity, acting on the CH-CH group of donors; IEA:UniProt.
DR GO; GO:0008202; P:steroid metabolic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR PANTHER; PTHR43400:SF7; FAD_BINDING_2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43400; FUMARATE REDUCTASE; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 9..496
FT /note="FAD-dependent oxidoreductase 2 FAD binding"
FT /evidence="ECO:0000259|Pfam:PF00890"
SQ SEQUENCE 512 AA; 54021 MW; E93EFE275199D96C CRC64;
MQDWTTECDV LVVGSGGGAL TGAYTAASQG LRTLVLEKTP LFGGTSAYSG AAVWLPGTAV
QERAGVGDST DKARTYLRAV VGDEEIDRQE AYVATAPEVV DLLERDPHIE FEWRAFPDYY
KAPGRMDYGR AINPLDLPSD EVGDLREVIR PEADVDRAGE PHPEGTLNGG RALIGRLLMA
LHGTGHAELR TGTAARSLVV EDGRVVGALA TNAAGETVRI RATRGVLLAA GGIEGNAALR
TENGTPGKAD WSMGPRGANT GDLLRAAVDI GADTALLDEA WWCPGVELPD GSGAFMVGVR
GGILVDTSGE RYLNESLPYD QFGRAMIEHG SRSSYLVFDS KEGGPVLPAI SIPHISAEKH
HAAGTWVSAD TIEELAEKIG VPADALRRTV EQFNDFAKHG VDEAFHRGED PYDNFFCPPG
TGADAPPNPA LSPVSQGPFH AARIVLSDLG TKGGVRTDAD ARVLRADGTP IDGLYAAGNT
SASLSGRFYP GPGVPLGTAM VFSYRAVQHM RN
//
