ID J2U726_9BURK Unreviewed; 931 AA.
AC J2U726;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE SubName: Full=DNA segregation ATPase, FtsK/SpoIIIE family {ECO:0000313|EMBL:EJL86982.1};
GN ORFNames=PMI16_03021 {ECO:0000313|EMBL:EJL86982.1};
OS Herbaspirillum sp. CF444.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Herbaspirillum.
OX NCBI_TaxID=1144319 {ECO:0000313|EMBL:EJL86982.1, ECO:0000313|Proteomes:UP000007296};
RN [1] {ECO:0000313|EMBL:EJL86982.1, ECO:0000313|Proteomes:UP000007296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CF444 {ECO:0000313|EMBL:EJL86982.1,
RC ECO:0000313|Proteomes:UP000007296};
RX PubMed=23045501; DOI=10.1128/JB.01243-12;
RA Brown S.D., Utturkar S.M., Klingeman D.M., Johnson C.M., Martin S.L.,
RA Land M.L., Lu T.Y., Schadt C.W., Doktycz M.J., Pelletier D.A.;
RT "Twenty-one genome sequences from Pseudomonas species and 19 genome
RT sequences from diverse bacteria isolated from the rhizosphere and
RT endosphere of Populus deltoides.";
RL J. Bacteriol. 194:5991-5993(2012).
CC -!- FUNCTION: Essential cell division protein that coordinates cell
CC division and chromosome segregation. The N-terminus is involved in
CC assembly of the cell-division machinery. The C-terminus functions as a
CC DNA motor that moves dsDNA in an ATP-dependent manner towards the dif
CC recombination site, which is located within the replication terminus
CC region. Translocation stops specifically at Xer-dif sites, where FtsK
CC interacts with the Xer recombinase, allowing activation of chromosome
CC unlinking by recombination. FtsK orienting polar sequences (KOPS) guide
CC the direction of DNA translocation. FtsK can remove proteins from DNA
CC as it translocates, but translocation stops specifically at XerCD-dif
CC site, thereby preventing removal of XerC and XerD from dif.
CC {ECO:0000256|ARBA:ARBA00024784}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJL86982.1}.
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DR EMBL; AKJW01000065; EJL86982.1; -; Genomic_DNA.
DR RefSeq; WP_007880904.1; NZ_AKJW01000065.1.
DR AlphaFoldDB; J2U726; -.
DR STRING; 1144319.PMI16_03021; -.
DR PATRIC; fig|1144319.3.peg.3062; -.
DR eggNOG; COG1674; Bacteria.
DR OrthoDB; 9807790at2; -.
DR Proteomes; UP000007296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 577..786
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT REGION 115..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 594..601
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 931 AA; 99696 MW; E40F538D4B6673A0 CRC64;
MRLFLLDWFG WSFLWILPLL GRVVVSLLSG KGLRGRGSIR IWLGTLMVLC ASSAVEAMLR
SQGDIALDSD FFGQALARGI TAGVGKLIGV LALMASGLLG LFWLFGRSRK AVAGDEPDTA
GLPVQASVPR RTQANIPPTV RNLPASQAPK LVKAQTPPQP LQPFGNLTRN LPHKRDPWPL
PNEMPRSANP SQTPAGNWPT APRSTEQPLK RPARPASEWA PFEALRPTQA MLARSTSTQA
AEPAPAHQAA PKPTLATSII SKPRITPIPG SSTKVRISTA SDRSQAIPTS LSATLAARLP
SHAATPALPQ VAQAAPAVTP GFTPAVPTSA GMQQIPAETI PTPLPFDLPE PEAVIAPEPF
SIIDTRVEPV WESVAAPTAP AAPAPLAAET PLLFDVPEQP YTAAPAAPMQ IRTWTQAPVA
APQPATSATV ETFTPYRPTD IPLPGIDLLD QGSDMPVEMD EAQLVEIGQL IEQRLKEFKV
PVTVLGAYAG PVITRFEIEP ALGVRGAQIV NLMKDLARAL GLTSIRVVET IPGKTCMGLE
LPNPKRQMIR LAEIIQSEAY ARSASHLTMA MGKDITGVPV ATDLARAPHM LVAGTTGSGK
SVAINAMILS LLYKATPDDV RLIMIDPKML ELSVYDGIPH LLAPVVTDMK LAAHALSWCV
AEMDKRYRLM SALGVRNLAG YNQKIADGIA AEKYVRNPFS LTPDAPEPLD RLPMIVVVID
ELADLMMVAG KKIEELIARL AQKARAAGIH LILATQRPSV DVITGLIKAN IPTRVAFQVS
SKIDSRTVLD QMGAETLLGH GDMLFLPPGS GYPQRVHGAF VSDEEVHRVV EHLKAHGEPQ
YEEAILAGPA SEEPQQGDMF GEPGDESDPL YDEAVAYVTR SRRASISSVQ RQFRIGYNRA
ARLVEQMEAA GILSSMSKSG SRDVLAPPPP D
//
