ID J2ZH63_9EURY Unreviewed; 526 AA.
AC J2ZH63;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase component {ECO:0000313|EMBL:EJN60040.1};
GN ORFNames=HSB1_21980 {ECO:0000313|EMBL:EJN60040.1};
OS Halogranum salarium B-1.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae.
OX NCBI_TaxID=1210908 {ECO:0000313|EMBL:EJN60040.1, ECO:0000313|Proteomes:UP000007813};
RN [1] {ECO:0000313|EMBL:EJN60040.1, ECO:0000313|Proteomes:UP000007813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B-1 {ECO:0000313|EMBL:EJN60040.1,
RC ECO:0000313|Proteomes:UP000007813};
RX PubMed=23144405; DOI=10.1128/JB.01815-12;
RA Kim K.K., Lee K.C., Lee J.S.;
RT "Draft Genome Sequence of the Extremely Halophilic Archaeon Halogranum
RT salarium B-1T.";
RL J. Bacteriol. 194:6659-6659(2012).
CC -!- COFACTOR:
CC Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC Evidence={ECO:0000256|ARBA:ARBA00001938};
CC -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007317}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJN60040.1}.
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DR EMBL; ALJD01000004; EJN60040.1; -; Genomic_DNA.
DR RefSeq; WP_009367280.1; NZ_ALJD01000004.1.
DR AlphaFoldDB; J2ZH63; -.
DR PATRIC; fig|1210908.3.peg.2104; -.
DR eggNOG; arCOG01706; Archaea.
DR OrthoDB; 56234at2157; -.
DR Proteomes; UP000007813; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR CDD; cd06849; lipoyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 4.10.320.10; E3-binding domain; 2.
DR InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR036625; E3-bd_dom_sf.
DR InterPro; IPR004167; PSBD.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR43178; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR PANTHER; PTHR43178:SF5; LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR Pfam; PF00198; 2-oxoacid_dh; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02817; E3_binding; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS51826; PSBD; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:EJN60040.1};
KW Pyruvate {ECO:0000313|EMBL:EJN60040.1};
KW Transferase {ECO:0000313|EMBL:EJN60040.1}.
FT DOMAIN 3..78
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 127..164
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
FT REGION 81..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 143..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..111
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 526 AA; 55614 MW; A06347B322FF4ACF CRC64;
MGSKDFKLPD VGEGVAEGEL VSWLVGPGDT VEEDQPVAEV ETDKALVEVP SPYNGTVKEL
HVEEGTMVPV GDVIITYEVE GEGDESAEAE PEPEAEETAE AEAEASAEAE TAESEQAETS
AKGGRVFAAP SARRLARELG VDIAAVSGSG PSGRVTDADV RQAAESEAGA SASAETESEA
QEGGGPRDVD VGGKSSVTKR GEAGNGQQPS DVEAAGRDRT LAAPATRRTA KEQGVDLNDV
PATEMRDGEA FVSAAAVTEY AEAQQAAQEA DAQAVAEAGA VADEETASAT SEGGISGERI
PYRGVRRTIG EAMQNSKFTA PHVTHHDSTD VSALVELRAE LKEVAAERDV RLSYMPFVMK
AIAAALKQYP YMNATLDEEN EEIVLRDEYH IGVATATDAG LMVPVVENVD QKGLLQIAEE
MNDKIERARD RSIGRDELRG STFTITNFGV VGGEYATPII NYPEVGIMGL GELKERAVVE
DGDVVARHTL PLSLSIDHRI LDGAVAAQFA NKVMEYLQHP KLLLLE
//
