ID   J2ZRH8_ACTNH            Unreviewed;      1160 AA.
AC   J2ZRH8;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   RecName: Full=Nephrocystin-3 {ECO:0000256|ARBA:ARBA00040387};
GN   ORFNames=HMPREF1129_2055 {ECO:0000313|EMBL:EJN85180.1};
OS   Actinomyces naeslundii (strain ATCC 12104 / DSM 43013 / CCUG 2238 / JCM
OS   8349 / NCTC 10301 / Howell 279).
OC   Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC   Actinomyces.
OX   NCBI_TaxID=1115803 {ECO:0000313|EMBL:EJN85180.1, ECO:0000313|Proteomes:UP000007814};
RN   [1] {ECO:0000313|EMBL:EJN85180.1, ECO:0000313|Proteomes:UP000007814}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12104 / DSM 43013 / CCUG 2238 / JCM 8349 / NCTC 10301 /
RC   Howell 279 {ECO:0000313|Proteomes:UP000007814};
RA   Durkin A.S., McCorrison J., Torralba M., Gillis M., Methe B., Sutton G.,
RA   Nelson K.E.;
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJN85180.1}.
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DR   EMBL; ALJK01000090; EJN85180.1; -; Genomic_DNA.
DR   RefSeq; WP_003781749.1; NZ_ALJK01000090.1.
DR   AlphaFoldDB; J2ZRH8; -.
DR   PATRIC; fig|1115803.3.peg.1035; -.
DR   eggNOG; COG0457; Bacteria.
DR   eggNOG; COG3903; Bacteria.
DR   Proteomes; UP000007814; Unassembled WGS sequence.
DR   GO; GO:0005871; C:kinesin complex; IEA:InterPro.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   InterPro; IPR002151; Kinesin_light.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR45641:SF1; NEPHROCYSTIN-3; 1.
DR   PANTHER; PTHR45641; TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870); 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF13374; TPR_10; 3.
DR   Pfam; PF13424; TPR_12; 4.
DR   PRINTS; PR00381; KINESINLIGHT.
DR   SMART; SM00028; TPR; 8.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 2.
PE   4: Predicted;
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803};
KW   Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT   DOMAIN          256..443
FT                   /note="NB-ARC"
FT                   /evidence="ECO:0000259|Pfam:PF00931"
FT   REGION          1133..1160
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1160 AA;  128162 MW;  46F8EB1504DCA7C9 CRC64;
     MADPLSLFAL SASITGLLMR GAAVAVDPSW SSAASLPSDA LNAWRSLRRL QQGRGGEENP
     LEASIKSRLQ KQVDAAHERY ERTSVTQSAL AGAVTEIEVA LRDLSEDETT VLEAVRFPDH
     FERYLRRRTA GRRQNIEAAA EPFFDDLTRI VADEFIYRAP GSRAFDIAAL KQLLAGQEQL
     LAGQERLIDQ YTKTYERLDR IIDSIDNIRN TRGQLHATPT RIHFGSRPMV ATNFIPRTGQ
     NQLVNAIFFH NEPRTVLTGM KGSGKTQLAA TIAAKCEDEE WPLVAWINAA SRKKLVATLY
     ELATLTGIDA PHDKTPDFTA RRFLDKLRSA DAADRLFIFD NVENLDDLKD LTPEGKGVRV
     IITTTRHLDW DSLGWHPITV GVFERDQSIT LLCERTGDTN RDAANQIAST LGDLPVAITQ
     AAATARNERF TLNEYLRSLN SLPLADTIDK QEGEHYPKAI STALWLACKA TIDSIKKKNS
     TQGQLSIHQI STLSLLAAPG VPTAWLEDYN DTENAKKSLS ALLNSSVCQI SADSKKTLIH
     RLQGRVFREN RLSTEIEMNA AVSVAISVLE SISAHTQDSP SKEQQETHNL IEQLSTIASQ
     EHSLPLFSDP TIATILARTL KKAWRLGMHQ IALALINPLT KASEALGVDH PDIITSRNSL
     ADAYLLEGQT EKAVALVQQN LKHSTTLIGS TEPAILTSLS TLAKASRDRG DLEGAASLFE
     QILTDRIRIL GPNHPDILTS RNSLAGTQQE LGRLEEAITL YEKNFEDSER ILGPHHPGTL
     TFRNNLAGAY QDLGRLGEAI NLLEQNLKDR TLILGPDHPD TLASRHNLAN AYQAAGRFDE
     AITLHQQNLE DSIRILGPDH PDTLASRHNL ANAYREMGRL DEAITLHQQN LEDSIHILGP
     DHPDTLASRH NLANAYQAAG RLDEAITLHQ QNLEDSIHIL GPHHPHTLTS RHNLAVAYHD
     AGRLNEAITL QEQNLKDFKN LLGPNHPHTL TSRHNLANAY QAAGRLDEAI TLYEQNLKDS
     EDLLGPHHPH TLASRNNLAS AYQDAGRLDK AIPLYEQTLE DRTRILGPHH PHTLASRNNL
     ASAYQDAGRL DKAIPLLEQT LEDSTHILGP HHPSTLTSRN NLAEAYRAAG RIEDAEKLFE
     TPSGSEQDGT EEDPDQMTGD
//