ID J3JJR2_ACTNH Unreviewed; 306 AA.
AC J3JJR2;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Dihydrodipicolinate synthetase family protein {ECO:0000313|EMBL:EJN84656.1};
GN ORFNames=HMPREF1129_1083 {ECO:0000313|EMBL:EJN84656.1};
OS Actinomyces naeslundii (strain ATCC 12104 / DSM 43013 / CCUG 2238 / JCM
OS 8349 / NCTC 10301 / Howell 279).
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=1115803 {ECO:0000313|EMBL:EJN84656.1, ECO:0000313|Proteomes:UP000007814};
RN [1] {ECO:0000313|EMBL:EJN84656.1, ECO:0000313|Proteomes:UP000007814}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12104 / DSM 43013 / CCUG 2238 / JCM 8349 / NCTC 10301 /
RC Howell 279 {ECO:0000313|Proteomes:UP000007814};
RA Durkin A.S., McCorrison J., Torralba M., Gillis M., Methe B., Sutton G.,
RA Nelson K.E.;
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|PIRNR:PIRNR001365}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJN84656.1}.
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DR EMBL; ALJK01000140; EJN84656.1; -; Genomic_DNA.
DR RefSeq; WP_003783117.1; NZ_ALJK01000140.1.
DR AlphaFoldDB; J3JJR2; -.
DR GeneID; 64257145; -.
DR PATRIC; fig|1115803.3.peg.1511; -.
DR eggNOG; COG0329; Bacteria.
DR Proteomes; UP000007814; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR CDD; cd00408; DHDPS-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR PANTHER; PTHR12128:SF72; 4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR PRINTS; PR00146; DHPICSNTHASE.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365}.
FT ACT_SITE 136
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT ACT_SITE 165
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT BINDING 210
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ SEQUENCE 306 AA; 32320 MW; 5F09C18306F5E5EF CRC64;
MDNRFTGVIP PVVTPFTAEG EVDLDSLDKV VEHLIVGGVD GLFALGSSGE VAYLTDSQRD
AVIERVVKKA AGRVPVLAGA IDTTAHRVIE QARRAVSLGA QAIVATCPFY ALNDADEIKE
HFRAIAKAVD VPVFAYDVPV RLGGAKLGCD LLVELGKEGV IAGVKDSSGN DVAFRRLVAA
NEAAGHPLAL LTGHECVVDG MLLLGADGLV PGYGNVDPVR YTEMWKASRE GKWDEVRRLQ
DEVCAGFEIV FVPQGRSADA TGIGAFKTAM EAIGIIATNE MAFPVQALKG ETKDAVLEIV
KAQGLI
//
