ID J3K0Y6_COCIM Unreviewed; 833 AA.
AC J3K0Y6;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=GTPase activating protein {ECO:0000313|EMBL:EAS27562.3};
GN ORFNames=CIMG_10167 {ECO:0000313|EMBL:EAS27562.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS27562.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; GG704915; EAS27562.3; -; Genomic_DNA.
DR RefSeq; XP_001239145.2; XM_001239144.2.
DR AlphaFoldDB; J3K0Y6; -.
DR STRING; 246410.J3K0Y6; -.
DR GeneID; 4558210; -.
DR KEGG; cim:CIMG_10167; -.
DR VEuPathDB; FungiDB:CIMG_10167; -.
DR InParanoid; J3K0Y6; -.
DR OMA; WWREQRG; -.
DR OrthoDB; 164430at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR PANTHER; PTHR22957:SF502; TBC1 DOMAIN FAMILY MEMBER 16; 1.
DR PANTHER; PTHR22957; TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001261}.
FT DOMAIN 439..667
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..805
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 833 AA; 94920 MW; D3E2B1C8569E1DDB CRC64;
MAGRSTQFTP PPSPPSPSAS FYDISDDEEG EYNTITHTKT GKGVKLLFSK SKVYVHPTPS
SKDNIPGFIA LIQQKPSPTD DGNRPSSSSS STSVSAASYL LAWVPESSLG DAYNTYVKVD
LSDSSSPPRQ SYLVPPLPTT TSHGDSIGLY AFAIPLTQIY SLLVRPPSLG WWFGSVVINT
KAGDSSPALF FHDSECESTI LQKKKKTKES FDPFEDGHMF WGGDEVLRWL KRYVEVYRSG
VDPNVYLINP SEEDKTSFGN LPGIDKASRP PGSTQTAPKP QRDAGMDPIT KALKETRWKV
LEQFSKITTF TRRTAQDLAE NPRVPPQVRR LMRNPEIQTL QDEFDSARLY LARWAMGIAE
QSERERNQRI WTAKDVLAME DSSVGEFEIL NMEAANMTIS ERRKTVTKEE WNSWFDSITG
RLQITPDEAK ERIFHGGLDP NDGVRKEAWL FLLGVYSWDS GEDERKAMMN SKRDEYVRLK
GGWWERMIES TSTAEDYEWW KEQKNRIEKD VHRTDRTIPL FAGEDIPHPD PDSPFAETGT
NVHLEQMKDM LLTYNEYNRH LGYVQGMSDL LAPIYAVMQD DAVAFWGFVG FMDRMERNFL
RDQSGMREQL LTLDQLVQLM DPQLYIHLQK TDSTNFFFFF RMFLVWFKRE FEWVDVLRLW
EALWTDYLSS SFHIFVALAI LDKHRDIIIA HLQHFDEILK YVNELSNTID LIPILSRAEA
LFYRFQKKVE TIDKKYNFPS APVRQRKPIP SGSARASQSQ SPPSQQSNPP QPSPSAPQVI
SASGVQGLSR RDSSNRQSPS AGDDTVQVIS PLLRKLLGKE VSRLERGERS SGQ
//
