ID J3K2Q6_COCIM Unreviewed; 359 AA.
AC J3K2Q6;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 03-MAY-2023, entry version 47.
DE SubName: Full=Small G-protein GPA2 {ECO:0000313|EMBL:EAS28393.3};
GN ORFNames=CIMG_09597 {ECO:0000313|EMBL:EAS28393.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS28393.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SIMILARITY: Belongs to the G-alpha family. G(q) subfamily.
CC {ECO:0000256|ARBA:ARBA00007976}.
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DR EMBL; GG704912; EAS28393.3; -; Genomic_DNA.
DR RefSeq; XP_001239976.1; XM_001239975.2.
DR AlphaFoldDB; J3K2Q6; -.
DR STRING; 246410.J3K2Q6; -.
DR GeneID; 4558953; -.
DR KEGG; cim:CIMG_09597; -.
DR VEuPathDB; FungiDB:CIMG_09597; -.
DR InParanoid; J3K2Q6; -.
DR OMA; ANSHWFK; -.
DR OrthoDB; 2897309at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0005834; C:heterotrimeric G-protein complex; IEA:InterPro.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR002975; Fungi_Gprotein_alpha.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF242; GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR01241; GPROTEINAFNG.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
SQ SEQUENCE 359 AA; 41091 MW; D52183F377E59E42 CRC64;
MGCSGSKEIS PEERQAIKQN ASIDKMIRMD KKTYDRTVKI LLLGAGESGK STIIKQMRII
HAGGFPEDER RQTRAIIYSN MIVAFKILLD IMEAEGIEFE AADTKSFAQV IEETEADVES
DEAFTDLNVR QAMKSMWADP GVQKAVAKGH EFALHDNLDY YFNSLDRIFT PGWLPNNQDM
LHSRLRTTGI TETLFELGQI NFRMMDVGGQ RSERKKWIHC FEGVQCLLFM VALSGYDQCL
VEDQTANQMH EAMMLFESLV NGEWFRRKPV ILFLNKIDLF KQKVPTSPVS KHFPDFKGPD
GDYQAATKFF SDRFKGMTRM PEREIYVHHT NATDTTLLKA TMDSVQDMII QKNLNNLVL
//
