ID J3K3M5_COCIM Unreviewed; 1246 AA.
AC J3K3M5;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Peroxisomal ATPase PEX1 {ECO:0000256|ARBA:ARBA00034532};
DE AltName: Full=Peroxin-1 {ECO:0000256|ARBA:ARBA00032509};
GN ORFNames=CIMG_07548 {ECO:0000313|EMBL:EAS28802.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS28802.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00034440};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00034440};
CC -!- SIMILARITY: Belongs to the AAA ATPase family.
CC {ECO:0000256|ARBA:ARBA00006914}.
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DR EMBL; GG704913; EAS28802.3; -; Genomic_DNA.
DR RefSeq; XP_001240385.1; XM_001240384.2.
DR AlphaFoldDB; J3K3M5; -.
DR STRING; 246410.J3K3M5; -.
DR GeneID; 4559944; -.
DR KEGG; cim:CIMG_07548; -.
DR VEuPathDB; FungiDB:CIMG_07548; -.
DR InParanoid; J3K3M5; -.
DR OMA; LSASWCA; -.
DR OrthoDB; 544017at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0007031; P:peroxisome organization; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd19526; RecA-like_PEX1_r2; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 3.10.330.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR029067; CDC48_domain_2-like_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015342; PEX1-N_C-lobe.
DR PANTHER; PTHR23077; AAA-FAMILY ATPASE; 1.
DR PANTHER; PTHR23077:SF12; PEROXISOME BIOGENESIS FACTOR 1; 1.
DR Pfam; PF00004; AAA; 2.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF09262; PEX-1N; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF54585; Cdc48 domain 2-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00674; AAA; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 559..710
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 883..1018
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 229..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 722..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1075..1098
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1163..1185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..756
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1246 AA; 134491 MW; 1A4359DCCD815872 CRC64;
MAPSNRKSAT TAEVVLVPLK NCLVNLPPSL VSLLVNANTP AQNVIVELQY RASSPGSSSP
GTASSQRYAY TGWTGMPSKR KLNPVIGKNS MNSSRGVSRD QEITVVEIDS IFGRVLGLND
GQKVGLLLHI DPPVAHTINI EPLTPTDWEI IELHANFLEL NLLSQIRALP NPSYSTAPSG
QAEKAHPLTL HLSPTSTANI IITSLTPAAP SSSPFAKIAP DAEVIVAPKV RPKSARPTRG
ENRSVASTGR KSIGGRSSSS TVRPKSRDSE SSSRGAVYLR GVDRGLASNW FNEEVGESSN
EGLKVWIHRD VLAKYELRGA AYVCVSVVRP AGLLPPVDPQ QQIQQKEQES AEAGEITRKV
IAKVYPWDES PDFSHAALSS VLCSTLGSDD MVGGVIRIEA APSQRPSIKS VKIFPFSVDA
SKKKEGLKFG GESAAYKEAL VERVKAVYGD PSSDVGILGG PITDGMILPT LEDKTRSLDF
EEAMIRFDPP PSTSADGKAT IGWVLGSDSG FTLEIQPAIG KPMETSLVSV PVDERVPKEI
PEMVGIDSVI NNCMSNLTRS SSILVTGGLG SGKTSLCYVL GRQLQEDYLF NVSYFPCRKL
VTDETRISMI KDTLHRLFLS ASWCARLGGR SIVILDDIDK LCPVETELQV GGENGRSRQV
SEIFCSIVRE FCSANSPVVL LATAQSKESL NNVIIGGHVV REIVSLKAPD KEGRRRVLEK
LTSEDKPPGT IPNKINGYSH SRKPSSQDSW LDPSNPATRP GSADKEDGFI LSRDIDFLDL
AGKTDGYMPG DLVLLVSRAR NEALIRTVQD FTSSSSAITL GTEDFEKALK GFTPASLRNV
TLTSSSTTFA AIGGLHGTRK TLLETLQYPT KYAPIFAQCP LRLRSGLLLY GFPGCGKTLL
ASAVAGECGL NFISVKGPEI LNKYIGASEK SVRDLFERAE AARPCILFFD EFDSIAPKRG
HDSTGVTDRV VNQLLTQMDG AEGLSGVYVL AATSRPDLID PALLRPGRLD KSLLCDMPNH
DDRVDIITTL AKKLKLSDEV MERIGTIADR TEGYSGADLQ AVVYNAHLEA IHDALGDRSS
DKPQSKSTPM PNGVDEAGGN QKAVKTFIQF LYDPDEHALA TSAGRGRASA TAPCLSPPAV
IAAKLEALKN IRRRQREIER GLSSDMSAED TVNGADPVSD NDKDGSNEIH IEWVHIERSL
ETTRCSISDV ERKRLNAIYR EFIEGRNGEM PTGEGAREIG GRTSLM
//
