ID J3K3P8_COCIM Unreviewed; 691 AA.
AC J3K3P8;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Manganese ion homeostasis {ECO:0000313|EMBL:EAS28836.3};
GN ORFNames=CIMG_07582 {ECO:0000313|EMBL:EAS28836.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS28836.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; GG704913; EAS28836.3; -; Genomic_DNA.
DR RefSeq; XP_001240419.1; XM_001240418.2.
DR AlphaFoldDB; J3K3P8; -.
DR GeneID; 4560043; -.
DR KEGG; cim:CIMG_07582; -.
DR VEuPathDB; FungiDB:CIMG_07582; -.
DR InParanoid; J3K3P8; -.
DR OMA; TIQNHLC; -.
DR OrthoDB; 54839at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:InterPro.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR033308; PGAP5/Cdc1/Ted1.
DR PANTHER; PTHR13315; METALLO PHOSPHOESTERASE RELATED; 1.
DR PANTHER; PTHR13315:SF4; METALLOPHOSPHOESTERASE, ISOFORM E; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 512..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 669..689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 562..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 691 AA; 77208 MW; 1D668B5642F1B6D8 CRC64;
MASALGASRS HRDHFVEPPG IIERICTSLP PIARPVLATL RAKGESVAAA YTRAQRRMRY
RRSGGIQAIL RPLFSVRNAL IALWILTLWW GERKVFRDAV GKCEWTNWEK WPEDAVPHHT
VLIADPQLVD PHTYPGRPWP LSSLTTYLSD LYLYRTHSLL QEKLRPDSTF FLGDLFDGGR
EWGTASSSSP DDRYKKYGND MWMKEYARFS RIFFDTFRLG GVDSAASPRG RKIIASLPGN
HDLGFGNGIQ LPVLERFRAY FGEGNRVDIL GNHTFASVDS VSLSAMDQVD PATGGSSTSS
PHSEQIWKPT EVFLNEFQTL KSRAIKEELL FLSGETEGYI SPHTVVDATV PTKPTISPAA
SDADFPTIVL THVPMYRKAG TPCGPLREHW PPSSTDPLPE SDERNAIRIG WGYQYQNVLT
PTISEDIIKK TGPVVQIYSG DDHDYCEITH REFSGAPKEI TVKSASFAMG VRRPGVQLAS
LWNPVDPKSG KSLHPTGSQT IENHLCLFPD QLAVFIQYAY VVVFSMLILL LHAISVTLRA
DHIPDASDPI LPLTRRFLED IPSSSTSSTS TSTSSLSAGE NRFSNRCGNG IVPRTASSSP
SNDGTRPVKY LQFGGSPGVS EKLERSSRDE WDFSDKVKER SWTGFRTTVG KDIGSRGSRR
SFLVFRRHFV SSLKWVAGVS FAWYFWLLWT W
//
