ID J3K5Y8_COCIM Unreviewed; 586 AA.
AC J3K5Y8;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Protein kinase activator Bem1 {ECO:0000313|EMBL:EAS29911.3};
GN ORFNames=CIMG_08657 {ECO:0000313|EMBL:EAS29911.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS29911.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; GG704913; EAS29911.3; -; Genomic_DNA.
DR RefSeq; XP_001241494.2; XM_001241493.2.
DR AlphaFoldDB; J3K5Y8; -.
DR STRING; 246410.J3K5Y8; -.
DR GeneID; 4559974; -.
DR KEGG; cim:CIMG_08657; -.
DR VEuPathDB; FungiDB:CIMG_08657; -.
DR InParanoid; J3K5Y8; -.
DR OMA; FICAHHN; -.
DR OrthoDB; 1368965at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05992; PB1; 1.
DR CDD; cd06890; PX_Bem1p; 1.
DR CDD; cd11878; SH3_Bem1p_1; 1.
DR CDD; cd11879; SH3_Bem1p_2; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR035550; Bem1/Scd2_PX.
DR InterPro; IPR035548; Bem1/Scd2_SH3_1.
DR InterPro; IPR035549; Bem1/Scd2_SH3_2.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15706:SF2; BUD EMERGENCE PROTEIN 1; 1.
DR PANTHER; PTHR15706; SH3 MULTIPLE DOMAIN; 1.
DR Pfam; PF00564; PB1; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00018; SH3_1; 2.
DR SMART; SM00666; PB1; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS51745; PB1; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:EAS29911.3};
KW Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transferase {ECO:0000313|EMBL:EAS29911.3}.
FT DOMAIN 28..93
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 150..212
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 309..429
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 509..584
FT /note="PB1"
FT /evidence="ECO:0000259|PROSITE:PS51745"
FT REGION 96..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 441..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 586 AA; 65560 MW; 96D976D3412B422F CRC64;
MRRSLKGDKD QKPQHVSITP KSAIAILPPK KVIRALYDYT PDPANTHELA FSKGDFFHVI
SREDDFDWYE ACNPLSSSAR GLVPVSFFEV IGKTERNSGG STGFPEDHRS HDLQSSDPSD
RNTLVGTEST TNTTKQGAQA RMSAIGKSAG AMVYGVVQYD FHAERPDELE ARAGEAIIVI
AQSNPEWFVA KPIGRLGGPG LIPVSFIEVR DMVTGQPVTD PHEAVKRAGV PRVEEWKKMT
AEYKNSSITL GKFETGGVQS ATAEIEKMSL NNSGHHNSND YYHQRNASKS QRYPNPNQQF
QQQRSQDYYS VPAPVQASIP RYCFDNDKYW YIIEAQMEDG RWWELSRYYH DFYDFQIALL
AQFEEEAGNK GGPRTLPFMP GPVTHVTNAI SNGRRQNLDE YIKKLLSMPP HISRCQLVRQ
LFAPRPGDFE IDPAAMADEY RLSSGSQPSS GHDASPSASR QSSQGQMNSY LNHQRNQGSV
SQSSVAQQPM MLRQGSALTQ GSISSGSNAI KIKVFFQDDL IVVRVPTDIT LQQLRDKIKD
RLKVDEDILL RYKDEPSRGF VELLSDADLE VAIQRNTKLM VYVGIA
//
