ID J3K9K1_COCIM Unreviewed; 326 AA.
AC J3K9K1;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 22-FEB-2023, entry version 38.
DE SubName: Full=Alkaline dihydroceramidase Ydc1 {ECO:0000313|EMBL:EAS31594.3};
GN ORFNames=CIMG_07073 {ECO:0000313|EMBL:EAS31594.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS31594.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the alkaline ceramidase family.
CC {ECO:0000256|ARBA:ARBA00009780}.
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DR EMBL; GG704912; EAS31594.3; -; Genomic_DNA.
DR RefSeq; XP_001243177.2; XM_001243176.2.
DR AlphaFoldDB; J3K9K1; -.
DR STRING; 246410.J3K9K1; -.
DR GeneID; 4561749; -.
DR KEGG; cim:CIMG_07073; -.
DR VEuPathDB; FungiDB:CIMG_07073; -.
DR InParanoid; J3K9K1; -.
DR OMA; IMFEPLR; -.
DR OrthoDB; 2910516at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.
DR GO; GO:0006672; P:ceramide metabolic process; IEA:InterPro.
DR InterPro; IPR008901; ACER.
DR PANTHER; PTHR46187; ALKALINE CERAMIDASE 3; 1.
DR PANTHER; PTHR46187:SF3; ALKALINE CERAMIDASE 3; 1.
DR Pfam; PF05875; Ceramidase; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 28..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 326 AA; 37709 MW; 997300B684AE8D8E CRC64;
MFHIPYPPAR TGFWSPVTST LNWCEEDYYA TIYFAEIVNS LTNALFLFLG VKGIISCRKN
GHDFIFQIAF IGYFIVGLGS LLFHSTLKYP MQLVDELSMI YTTCLMCYAT FSFSKSTKAR
AILGSSLLGL SIFITAYYHY LQDPRFHQNA YAILTVVVVL RSMWLMEVTL RSKWRRARAL
SASAHVNGGS NPCSSRDVQL SQNTRDLKIL NTMWFMVVFG LTSFLTGFLI WNLDNHYCST
FRGWRRSIGL PWGILLEGHG WWHLLTGTGA YIYIIWGIWL RHCLNGRQDE YELYWPRFYN
WPDVVRVEKE IPKPVHLNGT AAIKTH
//
