ID J3KFR3_COCIM Unreviewed; 1322 AA.
AC J3KFR3;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EAS34486.3};
GN ORFNames=CIMG_05510 {ECO:0000313|EMBL:EAS34486.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS34486.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GG704914; EAS34486.3; -; Genomic_DNA.
DR RefSeq; XP_001246069.2; XM_001246068.2.
DR GeneID; 4564413; -.
DR KEGG; cim:CIMG_05510; -.
DR VEuPathDB; FungiDB:CIMG_05510; -.
DR InParanoid; J3KFR3; -.
DR OMA; NMAWVEA; -.
DR OrthoDB; 2477520at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015693; P:magnesium ion transport; IEA:UniProt.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 1.20.58.340; Magnesium transport protein CorA, transmembrane region; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR045863; CorA_TM1_TM2.
DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR PANTHER; PTHR24203; ANKYRIN REPEAT FAMILY PROTEIN; 1.
DR PANTHER; PTHR24203:SF45; DIEGO, ISOFORM A; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF01544; CorA; 1.
DR SMART; SM00248; ANK; 5.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF144083; Magnesium transport protein CorA, transmembrane region; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 4.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1169..1189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1209..1229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1241..1264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1270..1293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 63..95
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 96..128
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 130..159
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 163..195
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 563..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..528
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..665
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..695
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1322 AA; 146785 MW; 131CF97EF5F2896B CRC64;
MNGDPSSSDR GSKGERNFQA SWNSRVSSDS QCLRLLDAVR RGDEDAVQCL LDDGANIRAK
NIDGETALHD AVRNGSLSMV QLLLDRGVDA EVADSKGAKA LYIAAETGDL ELVELLLRFD
VDVESFNPVA QSTAFHQAVI CGHPAVAGLL LAKGADIDAL VCDGHTPLLN AVIRNDLQAV
EFLLQNGANK KLRDDDGRRI EDFAVENPAM LALLQSDQLL QGPAITGPKT STKRQIRIPP
LSSDQPNKLK ACQGFEGTIV DFFVGTTEQR IEKTVPIYEL LYGKGPDSIM DPASRVEIDG
QQPTFRWYHL PANNIEWVHI LVNRHFSNRS SGATMLDEEF KSKLALSNST LRQYRVSTKH
SSFMRPQCRV VKSSPDSDPN DEIDNIVLFP LIYLHIPFLH FETSEGYHKM ARFLKALSEQ
FIHQSQPAPS LWRASRQPKK RPRERTLVPS LLDPLQNAGP SASAITSSDS SDSTQRTFTH
TKGKLRSAFE NLADVMRRGL HRGPITKDSS SGHEDDIEKG DHPGGDTKDF AEAIASSQRD
QLFGPTSSSN EKLTAENEAA TVISNAESTK ASKMAGNDRG KTGNSLSPSE KPSAANNTAK
TAISNVRSSK TSQMVDSNSE KLANSLSLSE KPGSEGERAE TVSLNIESTK TSPMVDNTSG
SLGRSPPPTV PAVEENTEGS VASQQNPSQR SGRSFWGLSA DDVDNLNFRA EESAFRTRNG
GDQTADLMNI DEHLVKGYFS PSNPGDSPLQ LRRTLDQYFY THLAHMSERN TGGQVIQRYT
QEHFAEPKMW MVDQLWLWIL NNDTIISCCP QRWDIFSSSF SHMTGTLFEP FPDQSGLENP
TVTRHRNSSL VPSSIELAQG KPKDKSKNEG NVVLGWMAGK QSKLIRKAAI QRKDKERGQF
FPAGSRDHLE TVFEPYSPRS SSEENRQRRA FLRKDPLNVH QMILKHLQSR ARDPITSVYA
LATLIADTCM ELFDEYRVPD EFQFFDFFER SIGDVIDQET QCFQSFAKSL TNKSPRETDA
VFSITKEATL LAEIKDISDE LGILKMVLHD QQEPREILAQ TIARHRTKDT NVKDKTNDSP
WARNTVLGSH LSRIKLMESL AERSYQALYN LLDLKQKQAN VLEALSSRKQ AENTFAQAEA
TQSLTEESLK LAQYTHDQSR EATRQGRTVL LFTVVTIIFL PLSFISAFFA INIDVFPWTS
SGRLPLDYIL KYLFGISSAV SIPFILIAFN QDRIAQWLKY ARGLAAAGWA FLLAAMVAIL
AVIWTQSLAT GIKAAVTIVI ICAILVALIV YTWHRLFGSM LNFTSSSDVS SRSLLSKGKY
FN
//
