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Database: UniProt
Entry: J3QMT8_MOUSE
LinkDB: J3QMT8_MOUSE
Original site: J3QMT8_MOUSE 
ID   J3QMT8_MOUSE            Unreviewed;      1135 AA.
AC   J3QMT8;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   05-JUL-2017, entry version 43.
DE   SubName: Full=Calcium-activated potassium channel subunit alpha-1 {ECO:0000313|Ensembl:ENSMUSP00000136447};
GN   Name=Kcnma1 {ECO:0000313|Ensembl:ENSMUSP00000136447,
GN   ECO:0000313|MGI:MGI:99923};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000136447, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000136447, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000136447,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000213|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000136447}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000136447};
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000136447}.
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DR   EMBL; AC154420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC154433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC154593; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC154795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CT010582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CT025624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; J3QMT8; -.
DR   SMR; J3QMT8; -.
DR   PaxDb; J3QMT8; -.
DR   PRIDE; J3QMT8; -.
DR   Ensembl; ENSMUST00000177634; ENSMUSP00000136447; ENSMUSG00000063142.
DR   MGI; MGI:99923; Kcnma1.
DR   eggNOG; KOG1420; Eukaryota.
DR   eggNOG; ENOG410YUX1; LUCA.
DR   GeneTree; ENSGT00530000063026; -.
DR   TreeFam; TF314283; -.
DR   Reactome; R-MMU-1296052; Ca2+ activated K+ channels.
DR   ChiTaRS; Kcnma1; mouse.
DR   Proteomes; UP000000589; Chromosome 14.
DR   Bgee; ENSMUSG00000063142; -.
DR   ExpressionAtlas; J3QMT8; baseline and differential.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0060072; F:large conductance calcium-activated potassium channel activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   InterPro; IPR024939; Ca-act_K_channel_Slo-1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003929; K_chnl_BK_asu.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR10027:SF37; PTHR10027:SF37; 1.
DR   Pfam; PF03493; BK_channel_a; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Proteomics identification {ECO:0000213|MaxQB:J3QMT8,
KW   ECO:0000213|PeptideAtlas:J3QMT8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268}.
FT   TRANSMEM     54     72       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     92    110       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    175    196       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    211    230       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    242    260       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       57    266       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1135 AA;  127571 MW;  79A978280E9AB2B6 CRC64;
     QEAQKINNGS SQADGTLKPV DEKEEVVAAE VGWMTSVKDW AGVMISAQTL TGRVLVVLVF
     ALSIGALVIY FIDSSNPIES CQNFYKDFTL QIDMAFNVFF LLYFGLRFIA ANDKLWFWLE
     VNSVVDFFTV PPVFVSVYLN RSWLGLRFLR ALRLIQFSEI LQFLNILKTS NSIKLVNLLS
     IFISTWLTAA GFIHLVENSG DPWENFQNNQ ALTYWECVYL LMVTMSTVGY GDVYAKTTLG
     RLFMVFFILG GLAMFASYVP EIIELIGNRK KYGGSYSAVS GRKHIVVCGH ITLESVSNFL
     KDFLHKDRDD VNVEIVFLHN ISPNLELEAL FKRHFTQVEF YQGSVLNPHD LARVKIESAD
     ACLILANKYC ADPDAEDASN IMRVISIKNY HPKIRIITQM LQYHNKAHLL NIPSWNWKEG
     DDAICLAELK LGFIAQSCLA QGLSTMLANL FSMRSFIKIE EDTWQKYYLE GVSNEMYTEY
     LSSAFVGLSF PTVCELCFVK LKLLMIAIEY KSANRESRIL INPGNHLKIQ EGTLGFFIAS
     DAKEVKRAFF YCKACHDDVT DPKRIKKCGC RRPVYVEDEQ PPTLSPKKKQ RNGGMRNSPN
     TSPKLMRHDP LLIPGNDQID NMDSNVKKYD STGMFHWCAP KEIEKVILTR SEAAMTVLSG
     HVVVCIFGDV SSALIGLRNL VMPLRASNFH YHELKHIVFV GSIEYLKREW ETLHNFPKVS
     ILPGTPLSRA DLRAVNINLC DMCVILSANQ NNIDDTSLQD KECILASLNI KSMQFDDSIG
     VLQANSQGFT PPGMDRSSPD NSPVHGMLRQ PSITTGVNIP IITELAKPGK LPLVSVNQEK
     NSGTHILMIT ELVNDTNVQF LDQDDDDDPD TELYLTQPFA CGTAFAVSVL DSLMSATYFN
     DNILTLIRTL VTGGATPELE ALIAEENALR GGYSTPQTLA NRDRCRVAQL ALLDGPFADL
     GDGGCYGDLF CKALKTYNML CFGIYRLRDA HLSTPSQCTK RYVITNPPYE FELVPTDLIF
     CLMQFDHNAG QSRASLSHSS HSSQSSSKKS SSVHSIPSTA NRPNRPKSRE SRDKQNATRM
     TRMGQEKKWF TDEPDNAYPR NIQIKPMSTH MANQINQYKS TSSLIPPIRE VEDEC
//
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