ID   J3S1P3_CROAD            Unreviewed;       448 AA.
AC   J3S1P3;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   22-FEB-2023, entry version 21.
DE   SubName: Full=V-type proton ATPase subunit S1 {ECO:0000313|EMBL:AFJ52059.1};
OS   Crotalus adamanteus (Eastern diamondback rattlesnake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus.
OX   NCBI_TaxID=8729 {ECO:0000313|EMBL:AFJ52059.1};
RN   [1] {ECO:0000313|EMBL:AFJ52059.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Venom gland {ECO:0000313|EMBL:AFJ52059.1};
RX   PubMed=23025625; DOI=10.1186/1471-2164-13-312;
RA   Rokyta D.R., Lemmon A.R., Margres M.J., Aronow K.;
RT   "The venom-gland transcriptome of the eastern diamondback rattlesnake
RT   (Crotalus adamanteus).";
RL   BMC Genomics 13:312-312(2012).
CC   -!- SIMILARITY: Belongs to the vacuolar ATPase subunit S1 family.
CC       {ECO:0000256|ARBA:ARBA00009037}.
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DR   EMBL; JU176536; AFJ52059.1; -; mRNA.
DR   AlphaFoldDB; J3S1P3; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.160.110; -; 1.
DR   InterPro; IPR008388; Ac45_acc_su.
DR   InterPro; IPR046756; VAS1/VOA1_TM.
DR   InterPro; IPR046755; VAS1_LD.
DR   PANTHER; PTHR12471:SF2; V-TYPE PROTON ATPASE SUBUNIT S1; 1.
DR   PANTHER; PTHR12471; VACUOLAR ATP SYNTHASE SUBUNIT S1; 1.
DR   Pfam; PF20520; Ac45-VOA1_TM; 1.
DR   Pfam; PF05827; VAS1_LD; 1.
PE   2: Evidence at transcript level;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..448
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003777509"
FT   TRANSMEM        404..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          242..382
FT                   /note="V-type proton ATPase subunit S1 luminal"
FT                   /evidence="ECO:0000259|Pfam:PF05827"
FT   DOMAIN          398..436
FT                   /note="V-type proton ATPase subunit S1/VOA1 transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF20520"
SQ   SEQUENCE   448 AA;  49087 MW;  171A8BF6345EC835 CRC64;
     MALRWVAGVL LLSLGLAAAH TGQVPLLAWS SHSSLWSPLA APHEGHVVTE AQLASLLDSA
     VDSGPHNVLL FLQEKLSIED FTVYGGVFGN KPDSAFPNLE NALGTAPSSL VLPSVDWFAA
     GAVPAFLKAK LGISPLHVDQ NTLQELRLNA SVPALLMVRL PYTTGSSLMA PKEVLTSNDE
     ILGQVLSALQ SEDIPYTAIL TALRPSRVLR DVSDVAPEKL GRQLLQKETV FAPVRYPTDG
     IPRILFWASN LSVTINKTLF DLTNLTFGPS AVVDVQESKW NSSFSELVLK YENIDRKQLR
     MRFQMTNASY PVSKRNWFVL HTVELVRPGE LPAVFNATYI TAPTNYSFSC ACVSSEPSLG
     GILVPRNATN WKLTIMRFQI QSYQLINETF SDASDCAGFF SPGLWMGLLT SFLLVAIFTY
     GLHMIMSLKT MDRFDDPKGP TISVPQTE
//