ID J4D906_THEOR Unreviewed; 1119 AA.
AC J4D906;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=NFACT RNA-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=TOT_030000383 {ECO:0000313|EMBL:BAM41120.1};
OS Theileria orientalis strain Shintoku.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Theileriidae; Theileria.
OX NCBI_TaxID=869250 {ECO:0000313|EMBL:BAM41120.1, ECO:0000313|Proteomes:UP000003786};
RN [1] {ECO:0000313|EMBL:BAM41120.1, ECO:0000313|Proteomes:UP000003786}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shintoku {ECO:0000313|EMBL:BAM41120.1,
RC ECO:0000313|Proteomes:UP000003786};
RX PubMed=22951932;
RA Hayashida K., Hara Y., Abe T., Yamasaki C., Toyoda A., Kosuge T.,
RA Suzuki Y., Sato Y., Kawashima S., Katayama T., Wakaguri H., Inoue N.,
RA Homma K., Tada-Umezaki M., Yagi Y., Fujii Y., Habara T., Kanehisa M.,
RA Watanabe H., Ito K., Gojobori T., Sugawara H., Imanishi T., Weir W.,
RA Gardner M., Pain A., Shiels B., Hattori M., Nene V., Sugimoto C.;
RT "Comparative genome analysis of three eukaryotic parasites with differing
RT abilities to transform leukocytes reveals key mediators of Theileria-
RT induced leukocyte transformation.";
RL MBio 3:e00204-e00212(2012).
CC -!- SIMILARITY: Belongs to the NEMF family.
CC {ECO:0000256|ARBA:ARBA00008318}.
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DR EMBL; AP011948; BAM41120.1; -; Genomic_DNA.
DR RefSeq; XP_009691421.1; XM_009693126.1.
DR AlphaFoldDB; J4D906; -.
DR STRING; 869250.J4D906; -.
DR EnsemblProtists; BAM41120; BAM41120; TOT_030000383.
DR GeneID; 20715563; -.
DR KEGG; tot:TOT_030000383; -.
DR VEuPathDB; PiroplasmaDB:TOT_030000383; -.
DR eggNOG; KOG2030; Eukaryota.
DR OrthoDB; 129892at2759; -.
DR Proteomes; UP000003786; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProt.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR InterPro; IPR021846; NFACT-C.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF11923; NFACT-C; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000003786}.
FT DOMAIN 484..620
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
FT DOMAIN 1027..1092
FT /note="NFACT protein C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11923"
FT REGION 661..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 882..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..773
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..847
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..867
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 898..917
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1119 AA; 129007 MW; DF633D992C3D8BDE CRC64;
MVRERLNAID VAISVANLKK TLDNITLVNI YDITNRLFIL KFSRNENKIY VLIEIGCRIH
TTQFLRSVDH LPSNFNAKLR KHLRNRRLRD VKQMSQDRII DFTFSSEEHA MHLIVQLFLP
GNIYLTDHEY KVLAVLKPKN TGDNFFKVGT NYVCDMEYNS WFEPVKRTLV EELVMGNKLT
DLVKTIFPSI HNGFILSVLK MNGNAEEDVK KLDRVYAMDE LDVVYEYVEA VRQCLVGLLT
RKDIVPGYIY RNAKGVMDDF GPFELQNAEY HEDYNYALDA FFTKNELVKQ EKKTESKKPT
KLTKIKADQD KRESKLMEEI MGYDKQIRVL EENIDIVDNC LNLTKALIAS GASWNDIYEQ
LQIQRKQNHP LVCYIKEINI PNQTLVFVSN PEGNERDDEP ERKELVEEQV VVLDYRLTGY
QNLKKFYINR KKAENKLERT KIGKEYALKK VAKSLSKQPE VKKGDRRTRE VKISSLRKRF
WFEKFYWFIT SQGYLVLAGR DSLQNELLVK KYLTKGDLYF HADIHGASSV ILKTNSQELI
KSSESAEVSE VEKAGGRGNE EEFIAKIRVS IEEAANFAVC HSNAWNDKFS VQSWWVYWHQ
VSKTPPTGEY VPQGSFVIRG KKNYLQPQKL EMGITYLFQV HPFQTLDNQE EAELAAKEEA
GNHGVNDERN EQEDEEDEQV GQGGEEVGEY SSTDDVEEDE EDYMEQENED YDDDEINQRE
YDEEENYMED NYEGEEEDEE DMDGALDQEG ESVDSVDEED EEDTYEVDED INDNIDHEDK
SVRMGNVVTI GECEANIVKR TRGRLATAYP LKAQLNKLKD RLEMLNLTKS SGDDEEEEEE
EEEESSDEEA GRTVKIMEPE RVSHTEEAIR KIRQRKATCV SPNLSELRKL INSENNKMDS
DEEEEVGEED EEDDDGSSAS MGGPKGAAVK VALKAEHELN VKKSSNRAMR LMSQKASKVK
KKYAQDDEET QELRRMLTGS KKMKQRTGAA TKTSFQVGPV TTDRAKESRL KGRDKEIPTI
SDRELETYMK QLSCLSRELK EDDDVLSVIP MCAPYSAIKH YRHVLKLVPG NAKKGTIATQ
SLQHFVKNDA QNAHYLKLIT TDQLTLTLIG NCKFTNAKM
//
