ID J4I057_9APHY Unreviewed; 902 AA.
AC J4I057;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=DUF221-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=FIBRA_07093 {ECO:0000313|EMBL:CCM04897.1};
OS Fibroporia radiculosa.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Fibroporiaceae; Fibroporia.
OX NCBI_TaxID=599839 {ECO:0000313|EMBL:CCM04897.1, ECO:0000313|Proteomes:UP000006352};
RN [1] {ECO:0000313|EMBL:CCM04897.1, ECO:0000313|Proteomes:UP000006352}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TFFH 294 {ECO:0000313|EMBL:CCM04897.1,
RC ECO:0000313|Proteomes:UP000006352};
RX PubMed=22247176; DOI=10.1128/AEM.06745-11;
RA Tang J.D., Perkins A.D., Sonstegard T.S., Schroeder S.G., Burgess S.C.,
RA Diehl S.V.;
RT "Short-read sequencing for genomic analysis of the brown rot fungus
RT Fibroporia radiculosa.";
RL Appl. Environ. Microbiol. 78:2272-2281(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; HE797171; CCM04897.1; -; Genomic_DNA.
DR RefSeq; XP_012184180.1; XM_012328790.1.
DR AlphaFoldDB; J4I057; -.
DR STRING; 599839.J4I057; -.
DR GeneID; 24099808; -.
DR HOGENOM; CLU_002458_2_0_1; -.
DR InParanoid; J4I057; -.
DR OrthoDB; 54187at2759; -.
DR Proteomes; UP000006352; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR InterPro; IPR022257; PHM7_ext.
DR PANTHER; PTHR13018:SF143; PHOSPHATE METABOLISM PROTEIN 7; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF12621; PHM7_ext; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006352};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 48..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..488
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 509..535
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 555..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 674..693
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 705..722
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 7..116
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 140..305
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 414..689
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT DOMAIN 831..897
FT /note="10TM putative phosphate transporter extracellular
FT tail"
FT /evidence="ECO:0000259|Pfam:PF12621"
FT REGION 305..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 876..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 769..807
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 902 AA; 100050 MW; 8DEF460ABD71DFE8 CRC64;
MSLVAGKRAQ PLSDSIFLWP WAVYKADYHK IKDVNGLDAY FFVRFLRMML RVLIPIWLIS
WVILLPVDSV GTTSGTSDSL TQFQFGNIGP GQQDRHWAHL VLVWAFTIWI WWNIRHEMSH
FVTTRQRWLI DPENATAQAN TMLVTGVPQR YLTEAAIKDV FSYLPGGVAK VWLNRDLKDM
PDLYERRLEA CKILESAETS LLNTAIKLHN KRIKKEAKAA KKSGKIVATA DEQRLTDGSI
IDTERGDALS LAERLVPQKK RPTRRLPLLS FLPSLPLIGT QVDSIEWARE EIAVTGAALR
SGRRTLAREV ERMSTSRDSR DSETGSADGH GHVSDHGHAG EDAEAVKPNP ETSLTYPPLN
SAFVLFNEQI AAHMAAQALT HHSPYRMAHK YLHVAPADII WGNLNMNPYE MKIRTAISWC
LTVGLIIVWA FPVAFIGAVS NIHSLCSTYG WLAWVCGLPP VIVGIISGIL PPALLAILMM
LLPIVLRLMA RFEGMPTRSS VELSLMTRYF LFQVIHSFLI VTLSSGIIAA LPQLVEDTNS
IPSMLASNLP KASTFFLTYI ILQGLSGSAS GFLDIISLAI YYVKLYLMGS TPRSIYNIKY
SLNSVQWGTA FPSVTLLVVI TVAYSIISPI INGLAVATFF LLYQLWKYRF LWQLGQPRAD
ETGGMFFPKA IQHVFVGLYL QLVCLAALFF LAQNGSKKPS AVPEGALTIV LIAFTAFFHI
IINNSYGPLI DYLPLTLAGQ DLELKDSNRA VTEQVLRENA SATSLDAEQQ EKRQGEGQQV
RSRRESSHPG KARVDTKEYA TRESDEIADA TGDVDVEQGV IQAASEDDLL GVDEEDGPKD
FYHPATVEPQ MTIWIPKDPL GLGEAEENVN REKGIAASTE NARMDGKGHV DVLGAPPEDG
SR
//
