ID J4KL42_BEAB2 Unreviewed; 1275 AA.
AC J4KL42;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=[histone H3]-trimethyl-L-lysine(9) demethylase {ECO:0000256|ARBA:ARBA00012900};
DE EC=1.14.11.66 {ECO:0000256|ARBA:ARBA00012900};
GN ORFNames=BBA_09517 {ECO:0000313|EMBL:EJP61549.1};
OS Beauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus)
OS (Tritirachium shiotae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria.
OX NCBI_TaxID=655819 {ECO:0000313|EMBL:EJP61549.1, ECO:0000313|Proteomes:UP000002762};
RN [1] {ECO:0000313|EMBL:EJP61549.1, ECO:0000313|Proteomes:UP000002762}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 2860 {ECO:0000313|EMBL:EJP61549.1,
RC ECO:0000313|Proteomes:UP000002762};
RX PubMed=22761991; DOI=10.1038/srep00483;
RA Xiao G., Ying S.H., Zheng P., Wang Z.L., Zhang S., Xie X.Q., Shang Y.,
RA St Leger R.J., Zhao G.P., Wang C., Feng M.G.;
RT "Genomic perspectives on the evolution of fungal entomopathogenicity in
RT Beauveria bassiana.";
RL Sci. Rep. 2:483-483(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-
CC [histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-
CC lysyl(9)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:60200, Rhea:RHEA-
CC COMP:15538, Rhea:RHEA-COMP:15542, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842,
CC ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61961;
CC EC=1.14.11.66; Evidence={ECO:0000256|ARBA:ARBA00000040};
CC -!- SIMILARITY: Belongs to the JHDM3 histone demethylase family.
CC {ECO:0000256|ARBA:ARBA00009711}.
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DR EMBL; JH725205; EJP61549.1; -; Genomic_DNA.
DR RefSeq; XP_008602836.1; XM_008604614.1.
DR AlphaFoldDB; J4KL42; -.
DR STRING; 655819.J4KL42; -.
DR GeneID; 19892529; -.
DR HOGENOM; CLU_001442_4_2_1; -.
DR InParanoid; J4KL42; -.
DR OrthoDB; 48111at2759; -.
DR Proteomes; UP000002762; Unassembled WGS sequence.
DR GO; GO:0140684; F:histone H3K9me2/H3K9me3 demethylase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15571; ePHD; 1.
DR Gene3D; 2.60.120.650; Cupin; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR003349; JmjN.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10694; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR PANTHER; PTHR10694:SF7; LYSINE-SPECIFIC DEMETHYLASE 4B-RELATED; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF02375; JmjN; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00545; JmjN; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS51183; JMJN; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002762};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 99..140
FT /note="JmjN"
FT /evidence="ECO:0000259|PROSITE:PS51183"
FT DOMAIN 379..542
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT DOMAIN 626..749
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT REGION 1..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 834..866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 920..940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1079..1114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1146..1179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..582
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 849..866
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1079..1102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1146..1173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1275 AA; 142820 MW; E4CB2FEDF7FE42BD CRC64;
MDSDSVNVAT GPASAPVVDD AQQHLESSDP SQLNFLHSPP DSNNAVKSDA SDSELSELEE
EPALDAPPHG LSASAEPPAA EDDKDDIGDV SPDHWSGTVP VFKPTMDQFK DFKKFMNKVD
SYGMTSGIIK IIPPQEWKDA QPNLDELVKQ IRVREPIKQD IMGFNGTYRQ VNILHGRSYN
LPQWRQLCDQ SEHQPPARRG ERRANTDRPK PPRPKPSAPK QPKTSMPKKR GRGRPAKNKP
KHDEAAAEPD NRPMTPVSPK PATDEPNEEK PEIVNSVETD APDPEAEQES APAPSRMGGR
MGGTKLAKEK TQSVSARRKN GRREGSVTID EEAFKNFDYK MDISDYTAER CEELERAYWK
TLTYAPPLYG ADMMGTLFED SADTWNLNKL PNLLDVLGTK IPGVNTAYLY LGMWKATFAW
HLEDVDLYSI NYLHFGAPKQ WYSISQADAP RFEKAMKSIW PADAKSCSQF LRHKGYLISP
QHLLSHYGIR VNKCLSYPGE FVVTYPYGYH SGYNLGYNCA EAVNFALDSW LPMGKIAKRC
ECSQAQDSVW IDVYEIERKL RGEPTPEYYE ETEDDEDEDD KDMSGLPSPP SNGVKFKDGR
KRKHGGDKGQ RLKIKKVRLR LKSRADPPCC LCPNDFVGMD VLPTNDGRKA HRMCAMFIPE
TYIDTVEGQD VVCNVNNIHR DRLDLKCLFC RSKRGACFQC SQKKCARAYH ATCAAAAGVF
IEEQDIPVYG QDGVEYKEQA FEFSCRFHRT RRDKKLDSLA LEGDERIHRA AEAVKSTEIC
QFQYAKGDIF AGMVIDNRHD EETFLISIVP SGERIEIEWK WLLIPDPSDY HLPKASPNAL
PLPASEKARN RLNAKRQDDD KPRKDDEFAE GYTWAEFNLF DDVVNKDQAK VDFAKPDQLW
HYLGKTSTEA KAQYTEDVTK QRHNPGGNFL ETIPKPPKPV TAPKYKQYRQ GVPSGYMHQQ
YNGGYIPPLS VGNTVMSRPY THQQYGHVQA SVPAYHQPAQ MGWNNTQSEG PRYSVHPSVY
QTYQYFQVHY NREPARYRTP YATYGGFING YETNYRTTLM ANGSQADMMR RLSFAGSLPS
AGIPQNSKHR TATHNAKISP AATPPSKTDK AKATPLQKVY QIPSKQSPVP LPPGFLAAMA
TSTPASAPVK ASQPAPPSTM SAAQATRATS SETLPAKPIE PAKISTTPVP LPSFALTPQQ
HASALKNMHT AQYNGDVDIN SSAADSTVAI LRQSNQAQLE QQEFVDVPGR ESMEFVDNMM
RNLRRASQQG MSPNP
//
