ID J4KN04_BEAB2 Unreviewed; 2049 AA.
AC J4KN04;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Urea carboxylase {ECO:0000313|EMBL:EJP64859.1};
GN ORFNames=BBA_06034 {ECO:0000313|EMBL:EJP64859.1};
OS Beauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus)
OS (Tritirachium shiotae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria.
OX NCBI_TaxID=655819 {ECO:0000313|EMBL:EJP64859.1, ECO:0000313|Proteomes:UP000002762};
RN [1] {ECO:0000313|EMBL:EJP64859.1, ECO:0000313|Proteomes:UP000002762}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 2860 {ECO:0000313|EMBL:EJP64859.1,
RC ECO:0000313|Proteomes:UP000002762};
RX PubMed=22761991; DOI=10.1038/srep00483;
RA Xiao G., Ying S.H., Zheng P., Wang Z.L., Zhang S., Xie X.Q., Shang Y.,
RA St Leger R.J., Zhao G.P., Wang C., Feng M.G.;
RT "Genomic perspectives on the evolution of fungal entomopathogenicity in
RT Beauveria bassiana.";
RL Sci. Rep. 2:483-483(2012).
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
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DR EMBL; JH725166; EJP64859.1; -; Genomic_DNA.
DR RefSeq; XP_008599353.1; XM_008601131.1.
DR STRING; 655819.J4KN04; -.
DR GeneID; 19889046; -.
DR HOGENOM; CLU_001643_0_0_1; -.
DR InParanoid; J4KN04; -.
DR OrthoDB; 313213at2759; -.
DR Proteomes; UP000002762; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd06850; biotinyl_domain; 1.
DR CDD; cd12148; fungal_TF_MHR; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 2.40.100.10; Cyclophilin-like; 2.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR003778; CT_A_B.
DR InterPro; IPR003833; CT_C_D.
DR InterPro; IPR029000; Cyclophilin-like_dom_sf.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR PANTHER; PTHR18866; CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR18866:SF33; METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR Pfam; PF02626; CT_A_B; 1.
DR Pfam; PF02682; CT_C_D; 1.
DR Pfam; PF04082; Fungal_trans; 1.
DR SMART; SM00796; AHS1; 1.
DR SMART; SM00797; AHS2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF50891; Cyclophilin-like; 2.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF160467; PH0987 N-terminal domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS00866; CPSASE_1; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000002762}.
FT DOMAIN 13..468
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 131..329
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT REGION 1430..1451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2049 AA; 222402 MW; 596447CF11FB13C1 CRC64;
MAPDSSSTEP LRHIRRVLIA NRGEIAVRCI KACKELGVHC ITIFTNADTT SLHAKLADES
VLLPGDNGTG YTDSASILEI CKRVGADAVI PGYGFLSENA EFADAVTAAG IVFVGPSSAS
IRAMGLKHEA RAIAVAANVP VIPGTSLLES ADDACVAARA LGFPVMLKAT GGGGGMGLQV
CHTEQEVTDA FSVVKSRGST LFKNSGVFLE KYYPSSRHVE VQVAGNGEIV VAFGERECSL
QRRHQKVIEE CPSPFVERHP GMREKMCQAA TNYASRLKYK SVGTVEFLVD DETADFFFLE
MNTRLQVEHG ITELCYGVDL VHLMLRQADH ERAGRLGLHS DELQRLVKLE PHGWAIEGRV
YAEVPLRNFA PAPGVLQHVG WAEGDGIRVD TWVSSGQNVT PYYDPLIAKI MVHSPDGRSA
AQATMLKALN NSALQGTQTN MEYLAKIIAS PMFVNGQTLT NSLSNFHFES CSLQVLDPGV
LTTLQDYPGR VNVGHGIPPG GPMDDLSARV ANILVGNEPG AELFEITLVG PELLFHEAAV
VAICGAELLV TLEEQTQPMW SRLIVGKGQI LKLGRVGKDG TRTYLAVKGG FPQVADYLGS
KSTAPELGIG GVQGRKLQAH DILALDPRSG TWAKQASPLS LPKEGLPIFD SDSATVIRCI
DGPYGSEDIL SPKGHTTLYE AEWSVSHNSS RSGVRLSGPR LKWARTSGGG GGSHPSNVFD
YGYPNGGVNF TGESPIIFAH DRPGLGGFAC PTTVCSAEMW KVGQLKTGNK VRFQSISFDD
ALQLSKSKEG YLQAIKAYSN GGTRTIPSPH VEVAKAPASS ILHQTPASGS HPRVTYRQGG
DTGIIVEYGE QLPDLRNTAC VYLLLQGLSR AQLPGVRGEP NFATLTVHFN QQSTPRESLL
ARLIQLDREA GEISGIQIPA RQLRLPVCLD HSSFAESNQR YMENIRPTAA YMPDNVEYLR
KNNALDSRQD VFDSILKAPW LTVAVGFFVG TPILYPLDPW RVITGQKYNP TRIYTPRGSI
GLGGSLAAIY PVAAPGGYQL MGRTLGGWDA AGNRPGFSPD KPWLFNQFDL VKFHQVSEEE
YTKIEQDFDA GRYVFDIVET TINMDQYIAQ FDEAARDPKY QEWKRRKEVA SKEMAELEEK
LYEEWVEAKR LATADAIEHE GDEESENVAL IKSPVDANVW RVLVKEGDEI QKGQTVAILE
AMKMEINIIA GDKEAGFVVA GIPQPPGSVL RALRPLKKIW AVGRESPLRR ASFARGHLNA
RNIWIDIYGR TQGSGPFNVL AVACSPGTSA SSLSPPSLPE NTNDRASAPR FGVAADVALA
EDSQQNCASP ATDERLPQAL SYLPVDMSPS VEVDWGLHAM QTEAFSLDVL PNEAEVIDNY
FMGIFHPTNA DMDPLLNTTS LTTVSGALPS TASPDTTSYV QTRTPAITNR NYASSTTPST
TTPQTAMRQS PSRIPGPLDA MEDVAAANPW TISSSAYARL QTEVNKFSHV LPAPFTLPSR
PKLSRFIASW MRGYHPHLPF LHIPTANIDT MKPMLVLTLA ATGSFYGFEH TEGYPMYVLA
KAMITSELEK RRVGATLCLL HGLPQYAELP TDHSASPIRE PAATHHSSPQ PPAFDVELLQ
ALLVLIMTMS WLDAPFAQEA LAMSSQLSTL TREALSQARL DDDDDANGGS WIDWGKAEER
RRSIFAAYFT LNIQTICFNV PPQLTNSEMK LLLPCCEAEF RAPNADAWKN SVLNTKPNNT
RNRDYQDCLA QLLAGKPLEP AAVISEFGNY LLVQSLLMQI YLERQAVSPL LGPSQNLPAA
TVAVYDRALA AWQQSCWDPA IETTSLDPST SAQGPVAFNA AAVLRLAHVH LGAGLQAHCE
LLTRDPRALA EAFSPVRNPL LLESAAARAA AAARTTTTKT AVRHAVCALR IPVRVGIAFV
ARGRTGHWSA QHAISNYACA LLLTHWLDSM ARVVAEHHGG DDDDGGGGLE AEERMLLGAV
ERLVEETHLE CSLGPKEDGG RPCPGRMRRL SIAALRLWAQ TCKGIQVYEI VHVVGEALSI
AADSIERGL
//
