ID J4KN16_BEAB2 Unreviewed; 1083 AA.
AC J4KN16;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Regulator of nonsense transcripts 1 {ECO:0000313|EMBL:EJP64919.1};
GN ORFNames=BBA_06094 {ECO:0000313|EMBL:EJP64919.1};
OS Beauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus)
OS (Tritirachium shiotae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria.
OX NCBI_TaxID=655819 {ECO:0000313|EMBL:EJP64919.1, ECO:0000313|Proteomes:UP000002762};
RN [1] {ECO:0000313|EMBL:EJP64919.1, ECO:0000313|Proteomes:UP000002762}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 2860 {ECO:0000313|EMBL:EJP64919.1,
RC ECO:0000313|Proteomes:UP000002762};
RX PubMed=22761991; DOI=10.1038/srep00483;
RA Xiao G., Ying S.H., Zheng P., Wang Z.L., Zhang S., Xie X.Q., Shang Y.,
RA St Leger R.J., Zhao G.P., Wang C., Feng M.G.;
RT "Genomic perspectives on the evolution of fungal entomopathogenicity in
RT Beauveria bassiana.";
RL Sci. Rep. 2:483-483(2012).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
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DR EMBL; JH725166; EJP64919.1; -; Genomic_DNA.
DR RefSeq; XP_008599413.1; XM_008601191.1.
DR AlphaFoldDB; J4KN16; -.
DR STRING; 655819.J4KN16; -.
DR GeneID; 19889106; -.
DR HOGENOM; CLU_001666_4_0_1; -.
DR InParanoid; J4KN16; -.
DR OrthoDB; 170190at2759; -.
DR Proteomes; UP000002762; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR CDD; cd21407; 1B_UPF1-like; 1.
DR CDD; cd18039; DEXXQc_UPF1; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR CDD; cd21400; ZBD_UPF1-like; 1.
DR Gene3D; 2.40.30.230; -; 1.
DR Gene3D; 6.10.140.1240; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR040812; UPF1_1B_dom.
DR InterPro; IPR018999; UPF1_CH/ZBD.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF18141; UPF1_1B_dom; 1.
DR Pfam; PF09416; UPF1_Zn_bind; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51997; UPF1_CH_RICH; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022806};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002762};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT DOMAIN 86..243
FT /note="Upf1"
FT /evidence="ECO:0000259|PROSITE:PS51997"
FT REGION 38..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..126
FT /note="C3H"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 108..136
FT /note="CC/SHH/C"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 154..184
FT /note="C4"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 969..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1046..1083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..55
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 991..1012
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1083 AA; 120007 MW; 63125141E020559B CRC64;
MEGAFTHVGN HLVSDSAAAI NAGNDDLSTL DPDERLLYGK YSDHGGRRRA DDDDNQTETF
EDDNDSLASI PVDEMVGLNL KNTDEEKELP AYACAYCGIH APASVVKCLV CNKWFCSARG
NSTSSHIINH LVRARHKEVQ LHPESALGDT ILECYSCGTK NSFLLGFIPA KSDSVVVLLC
RQPCAASASN KDMNWDPSRW EPLIKERAFL DWLVSAPSEA EQLRARHMSP NTIARLEEMW
KLEPNATISD LDKGQTVDDD PDPVLLKYDD AFHYQNIFGP LVKMESDYDK KLKEAQSEDN
LTVEWSQGLN NKHLATFNLR KIESGEVKLA VGDEMLLRYN GELREPWQGV GYVMKIPNSQ
SDEVCLELRK NGNDRSVPTD LSHNFSADYV WKATSYDRMQ LAMKTFAVDD MSVSGFIFHT
LLGHDVQLQP MKSNLPKKWS APGLPDLNQS QVDAIRSVLQ KPLSLIQGPP GTGKTVTSAT
IIYHLSKISG NQVLVCAPSN VAVDQLCERI HRTGLKVVRL TAKSREDVES SVSFLALHEQ
VRMSEHNSEF AKLSQLKNEA GELSSQDEKK FRQLTKAAER EILNNADVVC CTCVGAGDPR
LSKLKFRSVL IDESTQSAEP ECIIPLMLGC KQVVLVGDHK QLGPVIMNKK AAKAGLSQSL
FERLMQLRLQ PILLNTQYRM HPCLSEFPSN MFYDGSLQNG VTQEQRIRKD VDFPWPVAEM
PMMFWSNIGN EEISTSGTSY LNRTEASNVE KIVTRFFKAG VKPSEIGVIT PYEGQRSYIV
TTMQNAGTSK KEYYKSVEVA SVDAFQGREK DFIVLSCVRS NENQGIGFLS DPRRLNVALT
RAKYGVVILG NPRVLSKHEL WYNLLTHFRD RRCFVEGPLT NFQQCLLQFS KPRSHRQKLG
NQIPTGGYQN QNGRFNGSST IRDFDSSSMM SYVPDDVSSI HGSTFGGAAL NSAYPSMFSN
FAPEQWPGLP GVGAHGHRSG KSRARTAESV AGESVANSET TDTSSSIIGS RGVGQGGVSL
GAGLQDAVTG MRAISYTQSD RLRQYVESGA RNPPNNRYGG RRHDDDNRSV STAFHSQVGG
GYD
//
