ID J4KRX0_9GAMM Unreviewed; 539 AA.
AC J4KRX0;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Putative penicillin-binding protein 2 {ECO:0000313|EMBL:EJP71689.1};
GN ORFNames=NT01SARS_0165 {ECO:0000313|EMBL:EJP71689.1};
OS SAR86 cluster bacterium SAR86A.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; SAR86 cluster.
OX NCBI_TaxID=1123866 {ECO:0000313|EMBL:EJP71689.1, ECO:0000313|Proteomes:UP000010305};
RN [1] {ECO:0000313|EMBL:EJP71689.1, ECO:0000313|Proteomes:UP000010305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22170421; DOI=10.1038/ismej.2011.189;
RA Dupont C.L., Rusch D.B., Yooseph S., Lombardo M.J., Richter R.A., Valas R.,
RA Novotny M., Yee-Greenbaum J., Selengut J.D., Haft D.H., Halpern A.L.,
RA Lasken R.S., Nealson K., Friedman R., Venter J.C.;
RT "Genomic insights to SAR86, an abundant and uncultivated marine bacterial
RT lineage.";
RL ISME J. 6:1186-1199(2012).
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DR EMBL; JH611156; EJP71689.1; -; Genomic_DNA.
DR AlphaFoldDB; J4KRX0; -.
DR STRING; 1123866.NT01SARS_0165; -.
DR HOGENOM; CLU_009289_6_2_6; -.
DR Proteomes; UP000010305; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.30.450.330; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022645};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022645};
KW Reference proteome {ECO:0000313|Proteomes:UP000010305};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 55..159
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 235..526
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 539 AA; 60579 MW; 7459531F3C896A8A CRC64;
MRNKVKILNW RFFLICACIS FSILAVIYKV FSIQIKESNF LQNEGNKRYV KYKNISPVRG
SIFDKNNFPL AVTLVNYDLY ALRGFKKTNL LKLAENIEIE FNDVDQVFVK KTLLKKNISK
KEINKLKKLN IKNFEIETRH SRHYPLGEQI APLIGFYGTD GAQEGLEKSY DSILSGVPGK
KKYFKNAKQE IFSQPIEIEK AVQGKDIHLT IDATLQFFAY KYLVEGIRNN KAKAGTVVIL
DNKKGDVLAM ASYPSYNPNN PERKIQKNRV LVDAYELGSV LKPIMISKAI DLEIFNPEEY
IEIPRRLNLD DKIIVDTKNH EKLTPKEIIS VSSQIGASKI AIAIGYDELK QNYYDFGFTK
PVSLNFPSTA FGYMNIKEKV ADKELASLGY GYGITVSPFQ IASAYSVFAN KGFRKDFKII
QSDETTLEKI ITEESSIHIL DALKKVVKEG TGKAAEVRGF SEGGKTGTVH QIVRGSGYAE
DLYRASFVGI APLSEESLTI FVSIDDPGLN AYSGGSVAAP IFAKIAENSL NYMGYFEDE
//
