ID J4UN84_BEAB2 Unreviewed; 375 AA.
AC J4UN84;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=3-beta hydroxysteroid dehydrogenase/isomerase {ECO:0000313|EMBL:EJP66482.1};
GN ORFNames=BBA_04422 {ECO:0000313|EMBL:EJP66482.1};
OS Beauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus)
OS (Tritirachium shiotae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria.
OX NCBI_TaxID=655819 {ECO:0000313|EMBL:EJP66482.1, ECO:0000313|Proteomes:UP000002762};
RN [1] {ECO:0000313|EMBL:EJP66482.1, ECO:0000313|Proteomes:UP000002762}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 2860 {ECO:0000313|EMBL:EJP66482.1,
RC ECO:0000313|Proteomes:UP000002762};
RX PubMed=22761991; DOI=10.1038/srep00483;
RA Xiao G., Ying S.H., Zheng P., Wang Z.L., Zhang S., Xie X.Q., Shang Y.,
RA St Leger R.J., Zhao G.P., Wang C., Feng M.G.;
RT "Genomic perspectives on the evolution of fungal entomopathogenicity in
RT Beauveria bassiana.";
RL Sci. Rep. 2:483-483(2012).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR EMBL; JH725159; EJP66482.1; -; Genomic_DNA.
DR RefSeq; XP_008597741.1; XM_008599519.1.
DR AlphaFoldDB; J4UN84; -.
DR STRING; 655819.J4UN84; -.
DR GeneID; 19887434; -.
DR HOGENOM; CLU_007383_6_8_1; -.
DR InParanoid; J4UN84; -.
DR OrthoDB; 1133at2759; -.
DR Proteomes; UP000002762; Unassembled WGS sequence.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:EJP66482.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002762}.
FT DOMAIN 15..289
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 375 AA; 41515 MW; C0A384D189520E23 CRC64;
MSARSAPKGD LGKVLVVGGN GFLGHHIINQ ALDDWRCRHV VSVDLRCDRH RRADAQYHEC
DITDGPKLAA LFSEIRPDVV IHTASPVASD NAVHKELFRR VNVDGTRSVI EACQKAQVKA
LVYTSSASVV SDFQTDLHNA DERWPVIRAP QQIEYYSETK AAAEELVTRA NRAEPHPRFL
TTSIRPAGIF GEGDVQALAG LLGAYRTGKS KVQLGDNTNI FDFTYVGNVA HAHLLAARLL
LATASSSMSA PPLDHERVDG EVFFVTNDEP VYFWDFARAV WRAAGNEAGT EGVWQISRDM
SLLLGTASEI FNSIVGKKPT FTKQRATLST MTRYYNITKA KMVLGYEPQW TLQQGVDRGV
KWFLENEKET AAKAQ
//
