ID   J4UU79_BEAB2            Unreviewed;      1010 AA.
AC   J4UU79;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=Pro-apoptotic serine protease NMA111 {ECO:0000256|ARBA:ARBA00020338};
DE   AltName: Full=Pro-apoptotic serine protease nma111 {ECO:0000256|ARBA:ARBA00021524};
GN   ORFNames=BBA_01472 {ECO:0000313|EMBL:EJP69507.1};
OS   Beauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus)
OS   (Tritirachium shiotae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria.
OX   NCBI_TaxID=655819 {ECO:0000313|EMBL:EJP69507.1, ECO:0000313|Proteomes:UP000002762};
RN   [1] {ECO:0000313|EMBL:EJP69507.1, ECO:0000313|Proteomes:UP000002762}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ARSEF 2860 {ECO:0000313|EMBL:EJP69507.1,
RC   ECO:0000313|Proteomes:UP000002762};
RX   PubMed=22761991; DOI=10.1038/srep00483;
RA   Xiao G., Ying S.H., Zheng P., Wang Z.L., Zhang S., Xie X.Q., Shang Y.,
RA   St Leger R.J., Zhao G.P., Wang C., Feng M.G.;
RT   "Genomic perspectives on the evolution of fungal entomopathogenicity in
RT   Beauveria bassiana.";
RL   Sci. Rep. 2:483-483(2012).
CC   -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC       {ECO:0000256|ARBA:ARBA00002558}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family.
CC       {ECO:0000256|ARBA:ARBA00010541}.
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DR   EMBL; JH725152; EJP69507.1; -; Genomic_DNA.
DR   RefSeq; XP_008594791.1; XM_008596569.1.
DR   AlphaFoldDB; J4UU79; -.
DR   STRING; 655819.J4UU79; -.
DR   GeneID; 19884484; -.
DR   HOGENOM; CLU_003212_0_0_1; -.
DR   InParanoid; J4UU79; -.
DR   OrthoDB; 1779375at2759; -.
DR   Proteomes; UP000002762; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd00987; PDZ_serine_protease; 1.
DR   Gene3D; 2.30.42.10; -; 2.
DR   Gene3D; 2.40.10.120; -; 1.
DR   InterPro; IPR025926; PDZ-like_dom.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   PANTHER; PTHR46366; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR   PANTHER; PTHR46366:SF8; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR   Pfam; PF12812; PDZ_1; 2.
DR   Pfam; PF13365; Trypsin_2; 1.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022825};
KW   Protease {ECO:0000256|ARBA:ARBA00022825};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002762};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT   DOMAIN          388..464
FT                   /note="PDZ-like"
FT                   /evidence="ECO:0000259|Pfam:PF12812"
FT   DOMAIN          863..940
FT                   /note="PDZ-like"
FT                   /evidence="ECO:0000259|Pfam:PF12812"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1010 AA;  111728 MW;  A7D63B1008EF4BCB CRC64;
     MNGHSMAGAK RKSSGSPDRA PAPKRVPNGN HSHDEDTPDT ELIHYDDESD LVDEGDMYIG
     TPVSLGEWQD TIQKVVRNVV AIRFCQTCSF DTDPALTSEA TGFVVDSERG YILTNRHVVG
     SGPFWGHCVF DNHEEVDCYP VYRDPVHDFG ILRYDPKALK YMQVDGLDLT PDQAKVGVEI
     RVVGNDAGEK LSILSGVISR LDRNAPEYGE GYSDFNTCYY QANAAASGGS SGSPVVCKDG
     TAVALQAGGR SDGASTDYFL PLDRPLRALQ CIQQGKPVTR GDIQCQFLLK PFDECRRLGL
     SSHWEAAIRQ EFPDETNMLV GEIILPDGPS HEKIEEGDVL VKVNGQLITQ FLRLDDILDS
     SVGQPIKLQL QRGGQDIEVE IEVGDLHKIT PDRFVSVAGA SFHDISYQQA RLYAVAVKGV
     YVCESAGSFR FDNTDNGWII QSVDNKKVPD LDTFIQVMKG IPDKARVVVK YKHLRDLHTL
     NTTVIYIDRH WSAKMKLAVR NDITGLWDFS DLGDPLPPVA PVRRSAAFIE LDHMPDPSIA
     KLIRSFVHIN CTMPVKLDGF PKNRRWGMGL VIDAEKGIVL ISRAVVPYDL CDITITIADS
     IIVEGKVLFL HPLQNYTIVK YDPSLVDAPV ESARLSSEPL TQGAKTHFLG YNRIGRVVHG
     STTVTEITAV AIPANSAAPR YRAVNVDAIT IDSNLGSSCN SGVLVAPDGT VQALWLSYLG
     ERSSCSQRDE EYYLGLGTPT LLPVISAIQR GEMPKLRLLS VEFRSIQMSQ ASVMGVSDEW
     IKKVTQANRS HHQLFMVSKR TFERGSMPVS LLEGDIILTL NGKICTTITD FDIMYSNTVL
     DAVIMRENEE IQLQLPTVPA EDLETDHAVA FCGAILHRPH QAVRQQISKL HSEVYVSSRI
     RGSPAYQYGV APTNFITHVN GEPTPDLDSF IAATRQIPDN TYFRLKAVTF DCVPWVITMK
     KNDHYFPTME WIKDNSEPCG WRRVTYEGAA VTNGETVDGV PLPVEDAEME
//