ID J4X8P3_9ACTN Unreviewed; 657 AA.
AC J4X8P3;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Putative indolepyruvate ferredoxin oxidoreductase, alpha subunit {ECO:0000313|EMBL:EJU31886.1};
GN ORFNames=HMPREF1155_1609 {ECO:0000313|EMBL:EJU31886.1};
OS Slackia sp. CM382.
OC Bacteria; Actinomycetota; Coriobacteriia; Eggerthellales; Eggerthellaceae;
OC Slackia.
OX NCBI_TaxID=1111137 {ECO:0000313|EMBL:EJU31886.1, ECO:0000313|Proteomes:UP000004399};
RN [1] {ECO:0000313|EMBL:EJU31886.1, ECO:0000313|Proteomes:UP000004399}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM382 {ECO:0000313|EMBL:EJU31886.1,
RC ECO:0000313|Proteomes:UP000004399};
RA Durkin A.S., McCorrison J., Torralba M., Gillis M., Methe B., Sutton G.,
RA Nelson K.E.;
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|PIRSR:PIRSR006439-50};
CC Note=Binds 2 [4Fe-4S] clusters. In this family the first cluster has a
CC non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
CC {ECO:0000256|PIRSR:PIRSR006439-50};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJU31886.1}.
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DR EMBL; ALNO01000019; EJU31886.1; -; Genomic_DNA.
DR RefSeq; WP_009079149.1; NZ_ALNO01000019.1.
DR AlphaFoldDB; J4X8P3; -.
DR PATRIC; fig|1111137.3.peg.1679; -.
DR Proteomes; UP000004399; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0043805; F:indolepyruvate ferredoxin oxidoreductase activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR CDD; cd02008; TPP_IOR_alpha; 1.
DR CDD; cd07034; TPP_PYR_PFOR_IOR-alpha_like; 1.
DR Gene3D; 3.30.70.20; -; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR045025; HACL1-like.
DR InterPro; IPR017721; IorA.
DR InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR PANTHER; PTHR43710; 2-HYDROXYACYL-COA LYASE; 1.
DR PANTHER; PTHR43710:SF7; INDOLEPYRUVATE OXIDOREDUCTASE SUBUNIT IORA; 1.
DR Pfam; PF00037; Fer4; 1.
DR Pfam; PF01855; POR_N; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR PIRSF; PIRSF006439; Indolepyruvate_ferr_oxidored; 1.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 2.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|PIRSR:PIRSR006439-50};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR006439-50};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|PIRSR:PIRSR006439-
KW 50};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR006439-50}; Pyruvate {ECO:0000313|EMBL:EJU31886.1}.
FT DOMAIN 586..608
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 615..644
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT BINDING 595
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR006439-50"
FT BINDING 598
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR006439-50"
FT BINDING 601
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR006439-50"
FT BINDING 607
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR006439-50"
FT BINDING 624
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR006439-50"
FT BINDING 627
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR006439-50"
FT BINDING 630
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR006439-50"
FT BINDING 634
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR006439-50"
SQ SEQUENCE 657 AA; 69818 MW; 559EAE9B20F83A6D CRC64;
MPKKLLMGNE AFAHAALAAG ASVIAGYPGT PSSEVIETVA ARVASGGAHD VHVEWSTNEK
AALEMLAGAS YAGARTLFTC KQVGLNVAAD PLMSLNYVGV EGGCVLYVAD DPGPISSQTE
QDTRRFASFA KVPVFDPENI EQGMDMMAAA FELSEAYRTP VIVRPTTRVC HSSTYVDVPD
ETYGRPARGF TKDDSRWVIF PARSYRGHLE IVERLARIAE DFSDARGLGR FNPVEHHGES
ARLGIVCGGV STAYTREALA ILAAMHSDAL PAYRFMQIGT PYPFPANLVD SFVDGLDEII
VFEELDYVIE DELCALMGRR AMDGRAVARV RGKRTGDTQM AGENLVDNVL SQLERMLGFA
PDAADGVAAA ADAAMAAAAD RAGTETAEKR DLPDIEVPVR PPVLCAGCPH RGAFYAAKRA
ARRRKVVFSG DIGCYTLGNA KPLDAIDTCL CMGAGITMAQ GLKVAEPDAK QIAFIGDSTF
FASGMTGVAN AVYNAHDIVI CVLDNRTTAM TGDQPHPGTG DTLMGTKSDP LDVEAVLSAL
GVRMIEHANP HCLDESIDAV KRSLDFVGPS AVIFEAPCVN LIRPASACIV DQDACTKCRR
CITAIGCPAI GFMDGRITID ETICMGCGQC VQVCPYGAMT VPDGMPVEVR TGKEAHA
//
