ID J5EAN2_9MYCO Unreviewed; 524 AA.
AC J5EAN2;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Adenylate cyclase, family protein 3 {ECO:0000313|EMBL:EJO89076.1};
GN ORFNames=MCOL_V212540 {ECO:0000313|EMBL:EJO89076.1};
OS Mycobacterium colombiense CECT 3035.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium avium complex (MAC).
OX NCBI_TaxID=1041522 {ECO:0000313|EMBL:EJO89076.1, ECO:0000313|Proteomes:UP000006455};
RN [1] {ECO:0000313|EMBL:EJO89076.1, ECO:0000313|Proteomes:UP000006455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 3035 {ECO:0000313|EMBL:EJO89076.1,
RC ECO:0000313|Proteomes:UP000006455};
RX PubMed=21952541; DOI=10.1128/JB.05928-11;
RA Gonzalez-Perez M., Murcia M.I., Landsman D., Jordan I.K.,
RA Marino-Ramirez L.;
RT "Genome sequence of the Mycobacterium colombiense type strain, CECT 3035.";
RL J. Bacteriol. 193:5866-5867(2011).
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJO89076.1}.
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DR EMBL; AFVW02000003; EJO89076.1; -; Genomic_DNA.
DR AlphaFoldDB; J5EAN2; -.
DR STRING; 1041522.GCA_002105755_03435; -.
DR eggNOG; COG2114; Bacteria.
DR eggNOG; COG3850; Bacteria.
DR Proteomes; UP000006455; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06225; HAMP; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR PANTHER; PTHR43081:SF17; BLL5647 PROTEIN; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF00672; HAMP; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00304; HAMP; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 47..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 240..292
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 324..448
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 499..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 524 AA; 56145 MW; C617D05388C8AC0E CRC64;
MRTPWPLFSL SMLQADIIGA LFVLGFLRYA LPPEDRIQLQ DLPVLNLAIF ATALVVVFLT
GLAVTLRLLM PVFRWQRRDN MLAEADPAAT ELARSRALRM PFYRTLISIV AWAIGSVVFI
IASWSVARFA APVVAVSTGL GAAATSIIGY LQSERVLRPV AVAALRSGVP ENVKAPGVIL
RQILTWMLST AVPVLAIVLA VVADKTSLLH ATPEKLFTPI LLLACAALGI GLVSTLLVAM
SIADPLRQLR WALSEVQRGN YNAHMQIYDA SELGLLQAGF NDMVRDLSER QRLRDLFGRY
VGEDVARRAL ERGTELGGQE RDVAVLFVDL VGSTQLASTR PPAEVVHLLN EFFRVVVETV
GKHGGFVNKF QGDAALAIFG APIEHPDSPG GALAAARELH DALLPVIGSA EFGIGVSSGR
AIAGHIGAQA RFEYTVIGDP VNEAARLTEL AKLEPGHVLA SAIAVSGALD AEALCWDVGE
VVELRGRRAP TQLARPVHLA GTPDSEAPRA RAEEMSGETI GPGY
//
