ID J6IP59_9ENTR Unreviewed; 481 AA.
AC J6IP59;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=TldD protein {ECO:0000313|EMBL:EJU35490.1};
GN Name=tldD {ECO:0000313|EMBL:EJU35490.1};
GN ORFNames=HMPREF1144_2754 {ECO:0000313|EMBL:EJU35490.1};
OS Klebsiella sp. OBRC7.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=936565 {ECO:0000313|EMBL:EJU35490.1, ECO:0000313|Proteomes:UP000004118};
RN [1] {ECO:0000313|EMBL:EJU35490.1, ECO:0000313|Proteomes:UP000004118}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OBRC7 {ECO:0000313|EMBL:EJU35490.1,
RC ECO:0000313|Proteomes:UP000004118};
RA Durkin A.S., McCorrison J., Torralba M., Gillis M., Methe B., Sutton G.,
RA Nelson K.E.;
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Metalloprotease involved in CcdA degradation. Suppresses the
CC inhibitory activity of the carbon storage regulator (CsrA).
CC {ECO:0000256|ARBA:ARBA00025682}.
CC -!- SIMILARITY: Belongs to the peptidase U62 family.
CC {ECO:0000256|ARBA:ARBA00005836}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJU35490.1}.
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DR EMBL; ALNJ01000019; EJU35490.1; -; Genomic_DNA.
DR RefSeq; WP_004854666.1; NZ_ALNJ01000019.1.
DR AlphaFoldDB; J6IP59; -.
DR GeneID; 66557568; -.
DR PATRIC; fig|936565.3.peg.815; -.
DR Proteomes; UP000004118; Unassembled WGS sequence.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2290.10; PmbA/TldD superfamily; 1.
DR InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR InterPro; IPR025502; TldD.
DR InterPro; IPR035068; TldD/PmbA_N.
DR InterPro; IPR036059; TldD/PmbA_sf.
DR PANTHER; PTHR30624:SF4; METALLOPROTEASE TLDD; 1.
DR PANTHER; PTHR30624; UNCHARACTERIZED PROTEIN TLDD AND PMBA; 1.
DR Pfam; PF01523; PmbA_TldD_1st; 1.
DR Pfam; PF19290; PmbA_TldD_2nd; 1.
DR Pfam; PF19289; PmbA_TldD_3rd; 1.
DR PIRSF; PIRSF004919; TldD; 1.
DR SUPFAM; SSF111283; Putative modulator of DNA gyrase, PmbA/TldD; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670}.
FT DOMAIN 37..98
FT /note="Metalloprotease TldD/E N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01523"
FT DOMAIN 125..238
FT /note="Metalloprotease TldD/E central"
FT /evidence="ECO:0000259|Pfam:PF19290"
FT DOMAIN 246..479
FT /note="Metalloprotease TldD/E C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19289"
SQ SEQUENCE 481 AA; 51379 MW; C50BE8A6A27546F4 CRC64;
MSLNLVSEQL LSANGLNHQD LFTILGQLAE RRLDYGDLYF QSSYHESWVL EDSIIKDGSY
NIDQGVGVRA VSGEKTGFAY ADQISRLALE QSAQAARTIV RDHGDGKVHT LGGVEHRSLY
TSIDPLQSMS REEKLDILRR VDKTARAADK RVQEVSASLT GVYELILVAA TDGTLAADVR
PLVRLSVSVL VEEDGKRERG ASGGGGRFGY DYFLDSQDGD VRADVWAREA VRMALVNLTA
VAAPAGMLPV VLGAGWPGVL LHEAVGHGLE GDFNRRGTSV FSGHMGELVA SELCTVVDDG
TIAHRRGSLA IDDEGTPGQY NVLIENGILK GYMQDKLNAR LMGVAPTGNG RRESYAHLPM
PRMTNTYMLA GKSTPQEIIE SVDYGIYAPN FGGGQVDITS GKFVFSTSEA YLIEKGKVTK
AVKGATLIGS GIEAMQQISM VGNDLKLDSG VGVCGKEGQS VPVGVGQPTL KVDKLTVGGT
A
//
