ID J7GPL9_TRIVA Unreviewed; 95 AA.
AC J7GPL9;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=glutaminase {ECO:0000256|ARBA:ARBA00012918};
DE EC=3.5.1.2 {ECO:0000256|ARBA:ARBA00012918};
DE Flags: Fragment;
GN Name=TVAG_134820 {ECO:0000313|EMBL:AFP73246.1};
OS Trichomonas vaginalis.
OC Eukaryota; Metamonada; Parabasalia; Trichomonadida; Trichomonadidae;
OC Trichomonas.
OX NCBI_TaxID=5722 {ECO:0000313|EMBL:AFP73246.1};
RN [1] {ECO:0000313|EMBL:AFP73246.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TVC {ECO:0000313|EMBL:AFP73246.1};
RX PubMed=22855512; DOI=10.1128/JCM.00643-12;
RA Cornelius D.C., Robinson D.A., Muzny C.A., Mena L.A., Aanensen D.M.,
RA Lushbaugh W.B., Meade J.C.;
RT "Genetic Characterization of Trichomonas vaginalis Isolates by Use of
RT Multilocus Sequence Typing.";
RL J. Clin. Microbiol. 50:3293-3300(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-glutamine = L-glutamate + NH4(+);
CC Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001062};
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SIMILARITY: Belongs to the glutaminase family.
CC {ECO:0000256|ARBA:ARBA00011076}.
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DR EMBL; JX239651; AFP73246.1; -; Genomic_DNA.
DR AlphaFoldDB; J7GPL9; -.
DR VEuPathDB; TrichDB:TVAG_134820; -.
DR VEuPathDB; TrichDB:TVAGG3_0446800; -.
DR GO; GO:0004359; F:glutaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR015868; Glutaminase.
DR PANTHER; PTHR12544; GLUTAMINASE; 1.
DR PANTHER; PTHR12544:SF29; GLUTAMINASE; 1.
DR Pfam; PF04960; Glutaminase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFP73246.1"
FT NON_TER 95
FT /evidence="ECO:0000313|EMBL:AFP73246.1"
SQ SEQUENCE 95 AA; 10396 MW; E96AFD1503856875 CRC64;
VKKLSNSDKI SFLKEVYTSE METTDVNKSI AYYLRSKKIF SLNADEVLDL YIRNCSIGIN
ATELAHHGAV LANGGSDLVT GDEMVSKEAV KIVLA
//
