ID J7GYX1_CARRU Unreviewed; 321 AA.
AC J7GYX1;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=DNA-directed RNA polymerase subunit alpha {ECO:0000256|ARBA:ARBA00015972};
DE EC=2.7.7.6 {ECO:0000256|ARBA:ARBA00012418};
DE AltName: Full=RNA polymerase subunit alpha {ECO:0000256|ARBA:ARBA00033070};
DE AltName: Full=Transcriptase subunit alpha {ECO:0000256|ARBA:ARBA00032524};
GN Name=rpoA {ECO:0000313|EMBL:AFP83808.1};
GN ORFNames=A33Y_0171 {ECO:0000313|EMBL:AFP83808.1};
OS Candidatus Carsonella ruddii CS isolate Thao2000.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Zymobacter group; Candidatus Carsonella.
OX NCBI_TaxID=1202537 {ECO:0000313|EMBL:AFP83808.1, ECO:0000313|Proteomes:UP000003931};
RN [1] {ECO:0000313|EMBL:AFP83808.1, ECO:0000313|Proteomes:UP000003931}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CS {ECO:0000313|EMBL:AFP83808.1,
RC ECO:0000313|Proteomes:UP000003931};
RX PubMed=22821013; DOI=10.1093/molbev/mss180;
RA Sloan D.B., Moran N.A.;
RT "Genome reduction and co-evolution between the primary and secondary
RT bacterial symbionts of psyllids.";
RL Mol. Biol. Evol. 29:3781-3792(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550};
CC -!- SIMILARITY: Belongs to the RNA polymerase alpha chain family.
CC {ECO:0000256|ARBA:ARBA00007123}.
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DR EMBL; CP003542; AFP83808.1; -; Genomic_DNA.
DR AlphaFoldDB; J7GYX1; -.
DR STRING; 1202537.A33Y_0171; -.
DR KEGG; crc:A33Y_0171; -.
DR PATRIC; fig|1202537.3.peg.143; -.
DR HOGENOM; CLU_053084_0_0_6; -.
DR OrthoDB; 9805706at2; -.
DR Proteomes; UP000003931; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 2.170.120.12; DNA-directed RNA polymerase, insert domain; 1.
DR Gene3D; 3.30.1360.10; RNA polymerase, RBP11-like subunit; 1.
DR InterPro; IPR011262; DNA-dir_RNA_pol_insert.
DR InterPro; IPR011263; DNA-dir_RNA_pol_RpoA/D/Rpb3.
DR InterPro; IPR036603; RBP11-like.
DR InterPro; IPR011260; RNAP_asu_C.
DR InterPro; IPR036643; RNApol_insert_sf.
DR Pfam; PF01000; RNA_pol_A_bac; 1.
DR Pfam; PF03118; RNA_pol_A_CTD; 1.
DR Pfam; PF01193; RNA_pol_L; 1.
DR SMART; SM00662; RPOLD; 1.
DR SUPFAM; SSF47789; C-terminal domain of RNA polymerase alpha subunit; 1.
DR SUPFAM; SSF56553; Insert subdomain of RNA polymerase alpha subunit; 1.
DR SUPFAM; SSF55257; RBP11-like subunits of RNA polymerase; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 22..228
FT /note="DNA-directed RNA polymerase RpoA/D/Rpb3-type"
FT /evidence="ECO:0000259|SMART:SM00662"
SQ SEQUENCE 321 AA; 37604 MW; EEE695C620801E59 CRC64;
MIFNKKIFFI NKINIKKINN FRSIIRIEPF FNSYCDSIGN FIRRTLFLTS FCYYISHIKI
YNSNCIFSGI KGINEDVSTV IKNIKNIIFK IHNSSFAYLI IKKKGPCIVK AKDIFSDKKI
SIINPEKIIA NINFEINFFV LMKCVHSSFK KIIDINFENK LFKSKVFFLK NFNISLLNIN
YYIHKKSINK KIKKLFLDIE TNGSITPENC FKNCIFYIKK YFDLLFTILS FNNNNNIINN
NIINNNIINP LFLRSIDNLE LSIRSSNCLK SHNIFCIGDL IIKNEIDLIK IPKFGLKSLN
EVKNLLLQKG LSLNMKINYE L
//
