ID   J7H1G4_9ENTO            Unreviewed;       862 AA.
AC   J7H1G4;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
DE   Flags: Fragment;
OS   Coxsackievirus A16.
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Picornavirales; Picornaviridae; Ensavirinae; Enterovirus; Enterovirus A.
OX   NCBI_TaxID=31704 {ECO:0000313|EMBL:AFP89680.1};
RN   [1] {ECO:0000313|EMBL:AFP89680.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Z49-F5 {ECO:0000313|EMBL:AFP89680.1};
RA   He D.-L., Zhuang S.-J., Yan Q., Xu L.-F., Yang L.-S., Cheng T., Xia N.-S.;
RL   Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Interacts with capsid protein VP1 and capsid protein VP3 to
CC       form heterotrimeric protomers. {ECO:0000256|ARBA:ARBA00011474}.
CC   -!- SIMILARITY: Belongs to the picornaviruses polyprotein family.
CC       {ECO:0000256|ARBA:ARBA00008303}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JX127285; AFP89680.1; -; Genomic_RNA.
DR   GO; GO:0019028; C:viral capsid; IEA:InterPro.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0044694; P:pore-mediated entry of viral genome into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   CDD; cd00205; rhv_like; 3.
DR   Gene3D; 2.60.120.20; -; 3.
DR   InterPro; IPR003138; Pico_P1A.
DR   InterPro; IPR001676; Picornavirus_capsid.
DR   InterPro; IPR033703; Rhv-like.
DR   InterPro; IPR029053; Viral_coat.
DR   Pfam; PF02226; Pico_P1A; 1.
DR   Pfam; PF00073; Rhv; 3.
DR   SUPFAM; SSF88633; Positive stranded ssRNA viruses; 2.
PE   3: Inferred from homology;
KW   Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW   Eukaryotic host gene expression shutoff by virus
KW   {ECO:0000256|ARBA:ARBA00023247};
KW   Eukaryotic host translation shutoff by virus
KW   {ECO:0000256|ARBA:ARBA00022809};
KW   Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00022995};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Myristate {ECO:0000256|ARBA:ARBA00022707};
KW   Pore-mediated penetration of viral genome into host cell
KW   {ECO:0000256|ARBA:ARBA00023255};
KW   Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW   Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022595};
KW   Virion {ECO:0000256|ARBA:ARBA00022561};
KW   Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT   DOMAIN          93..292
FT                   /note="Picornavirus capsid"
FT                   /evidence="ECO:0000259|Pfam:PF00073"
FT   DOMAIN          352..521
FT                   /note="Picornavirus capsid"
FT                   /evidence="ECO:0000259|Pfam:PF00073"
FT   DOMAIN          629..772
FT                   /note="Picornavirus capsid"
FT                   /evidence="ECO:0000259|Pfam:PF00073"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         862
FT                   /evidence="ECO:0000313|EMBL:AFP89680.1"
SQ   SEQUENCE   862 AA;  94740 MW;  1F0B44B1AA754DA5 CRC64;
     MGSQVSTQRS GSHENSNSAS EGSTINYTTI NYYKDAYAAS AGRQDMSQDP KKFTDPVMDV
     IHEMAPPLKS PSAEACGYSD RVAQLTIGNS TITTQEAANI VIAYGEWPEY CPDTDATAVD
     KPTRPDVSVN RFFTLDTKSW AKDSKGWYWK FPDVLTEVGV FGQNAQFHYL YRSGFCVHVQ
     CNASKFHQGA LLVAVLPEYV LGTIAGGTGN ENSHPPYATT QPGQVGAVLT HPYVLDAGIP
     LSQLTVCPHQ WINLRTNNCA TIIVPYMNTV PFDSALNHCN FGLLVIPVVP LDFNTGATSE
     IPITVTIAPM CAEFAGLRQA VKQGIPTELK PGTNQFLTTD DGVSAPILPG FHPTPPIHIP
     GEVHNLLEIC RVETILEVNN LKTNETTPMQ RLCFPVSVQS KTGELCAAFR ADPGRDGPWQ
     STILGQLCRY YTQWSGSLEV TFMFAGSFMA TGKMLIAYTP PGGNVPADRI TAMLGTHVIW
     DFGLQSSVTL VVPWISNTHY RAHARAGYFD YYTTGIITIW YQTNYVVPIG APTTAYIVAL
     AAAQDNFTMK LCKDTEDIEQ TADIQGDPIA DMIDQTVNNQ VNRSLTALQV LPTAANTEAS
     SHRLGTGVVP ALQAAETGAS SNASDKNLIE TRCVLNHHST QETAIGNFFS RAGLVSIITM
     PTMGTQNTDG YANWDIDLMG YAQLRRKCEL FTYMRFDAEF TFVVAKPNGE LVPQLLQYMY
     VPPGAPKPTS RDSFAWQTAT NPSVFVKMTD PPAQVSVPFM SPASAYQWFY DGYPTFGEHL
     QADDLDYGQC PNNMMGTFSI RTVGTKKSPH SITLRVYMRI KHVRAWIPRP LRNQPYLFKT
     NPNYKGNDIK CTSTSRDKIT TL
//