ID J7HD82_9POLY Unreviewed; 801 AA.
AC J7HD82;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Large T-antigen {ECO:0000313|EMBL:AFP94187.1};
OS bat polyomavirus 2c.
OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC Sepolyvirales; Polyomaviridae; Betapolyomavirus;
OC Betapolyomavirus arplanirostris.
OX NCBI_TaxID=2758133 {ECO:0000313|EMBL:AFP94187.1, ECO:0000313|Proteomes:UP000153654};
RN [1] {ECO:0000313|EMBL:AFP94187.1, ECO:0000313|Proteomes:UP000153654}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R104 {ECO:0000313|EMBL:AFP94187.1};
RX PubMed=22971823; DOI=10.1099/vir.0.044149-0;
RA Fagrouch Z., Sarwari R., Lavergne A., Delaval M., de Thoisy B., Lacoste V.,
RA Verschoor E.J.;
RT "Novel polyomaviruses in South American bats and their relationship to
RT other members of the family Polyomaviridae.";
RL J. Gen. Virol. 93:2652-2657(2012).
CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000256|ARBA:ARBA00004147}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; JQ958887; AFP94187.1; -; Genomic_DNA.
DR Proteomes; UP000153654; Segment.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.40.1310.20; -; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 1.20.1050.70; Large T antigen, SV40, domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.510; Zinc finger, large T-antigen D1 domain; 1.
DR InterPro; IPR014015; Helicase_SF3_DNA-vir.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR010932; Lg_T_Ag_Polyomavir_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003133; T_Ag_DNA-bd.
DR InterPro; IPR017910; Znf_lg_T-Ag_D1-typ.
DR InterPro; IPR037102; Znf_lg_T-Ag_D1_dom_sf.
DR Pfam; PF06431; Polyoma_lg_T_C; 1.
DR Pfam; PF02217; T_Ag_DNA_bind; 1.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF55464; Origin of replication-binding domain, RBD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51206; SF3_HELICASE_1; 1.
DR PROSITE; PS51287; T_AG_OBD; 1.
DR PROSITE; PS51341; ZF_LTAG_D1; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00620}; Early protein {ECO:0000256|ARBA:ARBA00022518};
KW Host nucleus {ECO:0000256|ARBA:ARBA00022562};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000153654};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00671}.
FT DOMAIN 308..423
FT /note="T-ag OBD"
FT /evidence="ECO:0000259|PROSITE:PS51287"
FT DOMAIN 429..520
FT /note="T-ag D1-type"
FT /evidence="ECO:0000259|PROSITE:PS51341"
FT DOMAIN 559..719
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51206"
FT DNA_BIND 308..423
FT /note="T-ag OBD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00620"
FT REGION 98..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..291
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 801 AA; 90773 MW; 1162EABA185CA2E5 CRC64;
MDHALSSEER KELCNLLGIA RHCYGNYPLM KSNFKHACLK YHPDKGGDQE KMARLNFLWQ
KFLSYFMEMR RNIPEEDEEP IYGTTAFRHW WYRQHSRSHG RTQASTSGTS SRSSGYGSQP
SQSSSTGSQD GFQQRQQHGE SGDPDHSFDS EQQHNQHQST DSEQQHQQQN SKKQKQQSKK
SHHSSSSSSS RSDIPSSHGS HGFSGGNIYG NSSRVPPWDD DSLLCEESLS SSPSPEPAPT
STEEEPSFSE SSSFRGPPGT PSQSTDDDFS MPRSPPKRRR APSPPSSYSS TPPRPKKNKP
TSVPTDFPDD LLDCLSHAVY SNKTMSAFAI FTTQEKGKFF YEKLSEKFKV EYKGRFGCKE
GCILVIVTLT KHRVSAVKNF ALPFCTVSFL LIKGINKLME MYDLLQSEPY RLIEENKSLS
AHEFTEKKEI TCNWNLVADF AHEHGIDDPL LILAHYLDFA KPYPCNKCSS KSALKPHKSH
EQHHKNAKLF IESKSQKSIC LQAAETVQAK RRLLMLELTR EEMLCEKFKS ILEKLKDLDP
PDLKIYMAGV AWYYCLFDNF PQKVLKILKL LTENIPKKRN VLFKGPINSG KTSLAAAFLD
LLDGKALNVN CPADKLPFEL GCALDKFCVC FEDVKGQLGA NKDLQPGQGF HNLDNLRDHL
DGAVPVSLEK KHINKRHQIF PPCIITANEY AIPVTVAARI AYTLNFSLQP NLKASLDKNH
DLRKMRVLQS GTTLLLCLIW HLDIEDFKST LHDDVQTWKD ILRAEVGRGM YYNMVENVEK
GENPLFGIVD EEEEEEEPTN E
//
