ID J7LPT2_9SAUR Unreviewed; 222 AA.
AC J7LPT2;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 08-NOV-2023, entry version 34.
DE SubName: Full=Melanocortin-1 receptor {ECO:0000313|EMBL:AFR23276.1};
DE Flags: Fragment;
GN Name=MC1R {ECO:0000313|EMBL:AFR23276.1};
GN Synonyms=mc1r {ECO:0000313|EMBL:AGN32649.1};
OS Hemidactylus persicus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Gekkota; Gekkonidae; Gekkoninae;
OC Hemidactylus.
OX NCBI_TaxID=343427 {ECO:0000313|EMBL:AFR23276.1};
RN [1] {ECO:0000313|EMBL:AFR23276.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MVZHerp234385 {ECO:0000313|EMBL:AFR23276.1};
RA Carranza S., Arnold E.N.;
RT "A review of the geckos of the genus Hemidactylus (Squamata: Gekkonidae)
RT from Oman based on morphology, mitochondrial and nuclear data, with
RT descriptions of eight new species.";
RL Zootaxa 3378:1-95(2012).
RN [2] {ECO:0000313|EMBL:AGN32649.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JS103 {ECO:0000313|EMBL:AGN32649.1}, and JS104
RC {ECO:0000313|EMBL:AGN32650.1};
RA Smid J., Carranza S., Kratochvil L., Gvozdik V., Nasher A.K., Moravec J.;
RT "Out of Arabia: A complex biogeographic history of multiple vicariance and
RT dispersal events in the gecko genus Hemidactylus (Reptilia: Gekkonidae).";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; JQ957293; AFR23276.1; -; Genomic_DNA.
DR EMBL; KC818924; AGN32649.1; -; Genomic_DNA.
DR EMBL; KC818925; AGN32650.1; -; Genomic_DNA.
DR AlphaFoldDB; J7LPT2; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004977; F:melanocortin receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001908; MC3-5R.
DR InterPro; IPR001671; Melcrt_ACTH_rcpt.
DR PANTHER; PTHR22750; G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR22750:SF2; MELANOCYTE-STIMULATING HORMONE RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00534; MCRFAMILY.
DR PRINTS; PR00535; MELNOCORTINR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000313|EMBL:AFR23276.1};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 5..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 50..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..222
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFR23276.1"
FT NON_TER 222
FT /evidence="ECO:0000313|EMBL:AFR23276.1"
SQ SEQUENCE 222 AA; 25458 MW; C1C530048502C47C CRC64;
HSPMYYFICC LAVSDILVSI SNFVETLFIL LIDNRVMILQ DETARHMDNV MDVLICCSFM
ASLSFLGVIA IDRYITIFYA LRYHSIMTIQ RAVVIIAAIW VISTGASTIF IAFDDNKTVV
LCLLTYLLFM LTLIMGLYIH MFMLARRHAQ AISRMHRKHT APQRTSLKGA ITLSILLGVF
FVCWGPFFLH LILFVTCPNH PFCHCYFQYF NLCVILVICN SV
//
