ID J7M304_9NEOB Unreviewed; 169 AA.
AC J7M304;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:BAM37250.1};
OS Polypedates sp. KUHE 52131.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Rhacophoridae; Rhacophorinae;
OC Polypedates.
OX NCBI_TaxID=1198075 {ECO:0000313|EMBL:BAM37250.1};
RN [1] {ECO:0000313|EMBL:BAM37250.1}
RP NUCLEOTIDE SEQUENCE.
RA Kuraishi N., Matsui M., Hamidy A., Belabut D.M., Ahmad N., Panha S.,
RA Sudin A., Yong H.S., Jiang J.-P., Ota H., Thong H.T., Nishikawa K.;
RT "Phylogenetic and taxonomic relationships of the Polypedates leucomystax
RT complex (Amphibia).";
RL Zool. Scr. 42:54-70(2013).
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; AB728209; BAM37250.1; -; Genomic_DNA.
DR AlphaFoldDB; J7M304; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 101..169
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAM37250.1"
FT NON_TER 169
FT /evidence="ECO:0000313|EMBL:BAM37250.1"
SQ SEQUENCE 169 AA; 18961 MW; 277845B87856C16F CRC64;
YPGLRTHGTL ENIGGPMSGS RGGGLSPFTD AFEQVIEELL EEEQTIRQSE ENKDSDMYSS
RVMLSTQVPL EPPLLFLLEE YKNYLDAANM SMRVRRHSDP ARRGELSVCD SISEWVTAAD
KKTAVDMTGQ TVTVLEKVPV PKGQLKQYFY ETKCNPMGYM KDGCRGIDK
//