ID J7M448_STRP1 Unreviewed; 156 AA.
AC J7M448;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 2.
DT 13-SEP-2023, entry version 45.
DE RecName: Full=Transcription antitermination protein NusB {ECO:0000256|HAMAP-Rule:MF_00073};
DE AltName: Full=Antitermination factor NusB {ECO:0000256|HAMAP-Rule:MF_00073};
GN Name=nusB {ECO:0000256|HAMAP-Rule:MF_00073};
GN Synonyms=nus {ECO:0000313|EMBL:BAM30939.2};
GN ORFNames=M1GAS476_1622 {ECO:0000313|EMBL:BAM30939.2};
OS Streptococcus pyogenes M1 476.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1207470 {ECO:0000313|EMBL:BAM30939.2, ECO:0000313|Proteomes:UP000005248};
RN [1] {ECO:0000313|EMBL:BAM30939.2, ECO:0000313|Proteomes:UP000005248}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=476 {ECO:0000313|Proteomes:UP000005248};
RX PubMed=22965090; DOI=10.1128/JB.01265-12;
RA Miyoshi-Akiyama T., Watanabe S., Kirikae T.;
RT "Complete Genome Sequence of Streptococcus pyogenes M1 476, Isolated from a
RT Patient with Streptococcal Toxic Shock Syndrome.";
RL J. Bacteriol. 194:5466-5466(2012).
CC -!- FUNCTION: Involved in transcription antitermination. Required for
CC transcription of ribosomal RNA (rRNA) genes. Binds specifically to the
CC boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
CC {ECO:0000256|HAMAP-Rule:MF_00073}.
CC -!- SIMILARITY: Belongs to the NusB family. {ECO:0000256|ARBA:ARBA00005952,
CC ECO:0000256|HAMAP-Rule:MF_00073}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP012491; BAM30939.2; -; Genomic_DNA.
DR AlphaFoldDB; J7M448; -.
DR KEGG; spym:M1GAS476_1622; -.
DR HOGENOM; CLU_087843_3_2_9; -.
DR Proteomes; UP000005248; Chromosome 1.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006353; P:DNA-templated transcription termination; IEA:UniProtKB-UniRule.
DR GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-KW.
DR Gene3D; 1.10.940.10; NusB-like; 1.
DR HAMAP; MF_00073; NusB; 1.
DR InterPro; IPR035926; NusB-like_sf.
DR InterPro; IPR011605; NusB_fam.
DR InterPro; IPR006027; NusB_RsmB_TIM44.
DR NCBIfam; TIGR01951; nusB; 1.
DR PANTHER; PTHR11078:SF3; ANTITERMINATION NUSB DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11078; N UTILIZATION SUBSTANCE PROTEIN B-RELATED; 1.
DR Pfam; PF01029; NusB; 1.
DR SUPFAM; SSF48013; NusB-like; 1.
PE 3: Inferred from homology;
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00073};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00073};
KW Transcription antitermination {ECO:0000256|ARBA:ARBA00022814,
KW ECO:0000256|HAMAP-Rule:MF_00073};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00073}.
FT DOMAIN 18..146
FT /note="NusB/RsmB/TIM44"
FT /evidence="ECO:0000259|Pfam:PF01029"
SQ SEQUENCE 156 AA; 17712 MW; 28ED63F68F47FC03 CRC64;
MMRISWMTNS FQNSRRDLRE RAFQALFNIE MGAELLAASQ FAYGYDKVTG EDAQVLELPI
FLLSLVTGVN NHKEELDNLI STHLKKGWSL ERLTLTDKTL LRLGLFEIKY FDETPDRVAL
NEIIEVAKKY SDETSAKFIN GLLSQYVSGA PSANKS
//
