ID   J7M9L1_9NEOB            Unreviewed;       169 AA.
AC   J7M9L1;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|RuleBase:RU364086};
DE            Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE   Flags: Fragment;
GN   Name=BDNF {ECO:0000313|EMBL:BAM37237.1};
OS   Polypedates cf. mutus CIB 20081090.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Rhacophoridae; Rhacophorinae;
OC   Polypedates.
OX   NCBI_TaxID=1198052 {ECO:0000313|EMBL:BAM37237.1};
RN   [1] {ECO:0000313|EMBL:BAM37237.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Kuraishi N., Matsui M., Hamidy A., Belabut D.M., Ahmad N., Panha S.,
RA   Sudin A., Yong H.S., Jiang J.-P., Ota H., Thong H.T., Nishikawa K.;
RT   "Phylogenetic and taxonomic relationships of the Polypedates leucomystax
RT   complex (Amphibia).";
RL   Zool. Scr. 42:54-70(2013).
CC   -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC       located either in the central nervous system or directly connected to
CC       it. {ECO:0000256|RuleBase:RU364086}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR   EMBL; AB728196; BAM37237.1; -; Genomic_DNA.
DR   AlphaFoldDB; J7M9L1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR   PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01912; BDNFACTOR.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Growth factor {ECO:0000256|RuleBase:RU364086}.
FT   DOMAIN          101..169
FT                   /note="Nerve growth factor-related"
FT                   /evidence="ECO:0000259|SMART:SM00140"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAM37237.1"
FT   NON_TER         169
FT                   /evidence="ECO:0000313|EMBL:BAM37237.1"
SQ   SEQUENCE   169 AA;  18961 MW;  277845B87856C16F CRC64;
     YPGLRTHGTL ENIGGPMSGS RGGGLSPFTD AFEQVIEELL EEEQTIRQSE ENKDSDMYSS
     RVMLSTQVPL EPPLLFLLEE YKNYLDAANM SMRVRRHSDP ARRGELSVCD SISEWVTAAD
     KKTAVDMTGQ TVTVLEKVPV PKGQLKQYFY ETKCNPMGYM KDGCRGIDK
//