ID J7Q3L5_METSZ Unreviewed; 384 AA.
AC J7Q3L5;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Cobalamin synthesis protein P47K {ECO:0000313|EMBL:CCJ05979.1};
GN OrderedLocusNames=BN69_0528 {ECO:0000313|EMBL:CCJ05979.1};
OS Methylocystis sp. (strain SC2).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Methylocystaceae; Methylocystis.
OX NCBI_TaxID=187303 {ECO:0000313|EMBL:CCJ05979.1, ECO:0000313|Proteomes:UP000005263};
RN [1] {ECO:0000313|EMBL:CCJ05979.1, ECO:0000313|Proteomes:UP000005263}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC2 {ECO:0000313|EMBL:CCJ05979.1,
RC ECO:0000313|Proteomes:UP000005263};
RX PubMed=23045511; DOI=10.1128/JB.01446-12;
RA Dam B., Dam S., Kube M., Reinhardt R., Liesack W.;
RT "Complete Genome Sequence of Methylocystis sp. Strain SC2, an Aerobic
RT Methanotroph with High-Affinity Methane Oxidation Potential.";
RL J. Bacteriol. 194:6008-6009(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC subfamily. {ECO:0000256|ARBA:ARBA00034320}.
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DR EMBL; HE956757; CCJ05979.1; -; Genomic_DNA.
DR RefSeq; WP_014890013.1; NC_018485.1.
DR AlphaFoldDB; J7Q3L5; -.
DR STRING; 187303.BN69_0528; -.
DR KEGG; msc:BN69_0528; -.
DR PATRIC; fig|187303.17.peg.582; -.
DR eggNOG; COG0523; Bacteria.
DR HOGENOM; CLU_017452_0_1_5; -.
DR OrthoDB; 9808822at2; -.
DR Proteomes; UP000005263; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd03112; CobW-like; 1.
DR Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR036627; CobW-likC_sf.
DR InterPro; IPR011629; CobW-like_C.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13748:SF62; COBW DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13748; COBW-RELATED; 1.
DR Pfam; PF02492; cobW; 1.
DR Pfam; PF07683; CobW_C; 1.
DR SMART; SM00833; CobW_C; 1.
DR SUPFAM; SSF90002; Hypothetical protein YjiA, C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT DOMAIN 278..372
FT /note="CobW C-terminal"
FT /evidence="ECO:0000259|SMART:SM00833"
FT REGION 216..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 384 AA; 43305 MW; 7F668242A5F216C5 CRC64;
MTDKIPVTVI TGYLGAGKTT LLNRILTEQH GRRYAVIVNE FGEIGIDNDL VVGADEEVFE
MNNGCICCTV RGDLIRIIEG LMRRRGKFDA IIVETTGLAN PAPVAQTFFM DADVKEAARL
DAVVTVADAK WLSERLKDAP EAKSQIAFAD VIVLNKTDLV SDEELADVEG RIRAINPYAA
LHRAVRSGVP LQAVLERNAF DLDRILEIEP AFLDAEESSH DHDDVHECGP DCGHDHHEHD
HPDHDHDHDH DHGHAHEHKH ENHHAPRAGM QHFHDDEMHS VSIRHDGPVD PERFVPWLNE
LIQRDGPDIL RSKGIIAFRD EPRRFVFQGV HQILDGDLQR EWKEGEKRES RLVFIGRKLK
EQEIREGFEK IVLGASAAQE TSHS
//
