ID J7QNN4_METSZ Unreviewed; 625 AA.
AC J7QNN4;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=BN69_1547 {ECO:0000313|EMBL:CCJ06998.1};
OS Methylocystis sp. (strain SC2).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Methylocystaceae; Methylocystis.
OX NCBI_TaxID=187303 {ECO:0000313|EMBL:CCJ06998.1, ECO:0000313|Proteomes:UP000005263};
RN [1] {ECO:0000313|EMBL:CCJ06998.1, ECO:0000313|Proteomes:UP000005263}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC2 {ECO:0000313|EMBL:CCJ06998.1,
RC ECO:0000313|Proteomes:UP000005263};
RX PubMed=23045511; DOI=10.1128/JB.01446-12;
RA Dam B., Dam S., Kube M., Reinhardt R., Liesack W.;
RT "Complete Genome Sequence of Methylocystis sp. Strain SC2, an Aerobic
RT Methanotroph with High-Affinity Methane Oxidation Potential.";
RL J. Bacteriol. 194:6008-6009(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; HE956757; CCJ06998.1; -; Genomic_DNA.
DR AlphaFoldDB; J7QNN4; -.
DR STRING; 187303.BN69_1547; -.
DR KEGG; msc:BN69_1547; -.
DR PATRIC; fig|187303.17.peg.1684; -.
DR eggNOG; COG0784; Bacteria.
DR eggNOG; COG4191; Bacteria.
DR eggNOG; COG5278; Bacteria.
DR HOGENOM; CLU_000445_114_51_5; -.
DR Proteomes; UP000005263; Chromosome.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd16919; HATPase_CckA-like; 1.
DR CDD; cd19410; HK9-like_sensor; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR007891; CHASE3.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43065:SF10; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3; 1.
DR PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR Pfam; PF05227; CHASE3; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:CCJ06998.1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Transferase {ECO:0000313|EMBL:CCJ06998.1}.
FT DOMAIN 254..478
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 504..619
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT MOD_RES 554
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 625 AA; 68406 MW; 1271FFFDCB8DC264 CRC64;
MKMTVTVTLP KKAVSWAIFG FLVAAIGGAA ISLQKQVAAQ TWVEHTLYVR TALLQTLSTV
QDAETSQRGF LLTGDDTFLE PFRNADRTIG ERLHALERAI SDNEEQMQRL KRLRSVVADR
LAALQKHIQE RGASPDATFA DRLKNGKRLM DQARSIIAEM LGEEDRLLTT RNAEMRWTLT
LTQMGVAGAL LSAALLGWAT LKDRQRQVVE LQTANAALRI ALKQAADESE RRERVEGQLR
QSQKMQAVGQ LTGGLAHDFN NMLAVIVGCL NLLKRTMARG EVDKDGLIDK AMECVDRAAA
LTHRLLAFSR QQPLAPQTVD ANKLVGGMAE MIRRTLGEAV NVETVLASGV WRIHVDPNQL
ESALLNLAVN ARDAMNDEGK VTIETSNAYI DDHYAREHAE VKEGQYVLVA VSDTGAGMPP
EVIAKAFEPF FTTKGPGKGT GLGLSQVFGF VKQSGGHIKI YSELGQGTTV KIYLPRFVGE
GEVAAPIHQA NQLQRAMRGS PEMLILVVED EDRMRSVAVA MFKDLGYSVL AAGNAAEALA
LINANPHIDL LFTDIVMPDM NGRALAEEAL RRRPDLKVVF TTGFSRNAVI HNGVLDRGVN
FLPKPFSIEQ LAQKMSAVLG VMETT
//
