ID J7T9X4_9FIRM Unreviewed; 639 AA.
AC J7T9X4;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Tetracycline resistance protein TetM {ECO:0000313|EMBL:EJO23765.1};
GN Name=tetM {ECO:0000313|EMBL:EJO23765.1};
GN ORFNames=HMPREF1148_2125 {ECO:0000313|EMBL:EJO23765.1};
OS Selenomonas sp. FOBRC6.
OC Bacteria; Bacillota; Negativicutes; Selenomonadales; Selenomonadaceae;
OC Selenomonas.
OX NCBI_TaxID=936572 {ECO:0000313|EMBL:EJO23765.1, ECO:0000313|Proteomes:UP000006984};
RN [1] {ECO:0000313|EMBL:EJO23765.1, ECO:0000313|Proteomes:UP000006984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FOBRC6 {ECO:0000313|EMBL:EJO23765.1,
RC ECO:0000313|Proteomes:UP000006984};
RA Durkin A.S., McCorrison J., Torralba M., Gillis M., Methe B., Sutton G.,
RA Nelson K.E.;
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Abolishes the inhibitory effect of tetracyclin on protein
CC synthesis by a non-covalent modification of the ribosomes.
CC {ECO:0000256|ARBA:ARBA00003987}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJO23765.1}.
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DR EMBL; ALKG01000006; EJO23765.1; -; Genomic_DNA.
DR RefSeq; WP_002602099.1; NZ_ALKG01000006.1.
DR AlphaFoldDB; J7T9X4; -.
DR SMR; J7T9X4; -.
DR STRING; 936572.HMPREF1148_2125; -.
DR GeneID; 85010053; -.
DR PATRIC; fig|936572.3.peg.70; -.
DR eggNOG; COG0480; Bacteria.
DR Proteomes; UP000006984; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR CDD; cd03711; Tet_C; 1.
DR CDD; cd03690; Tet_II; 1.
DR CDD; cd16258; Tet_III; 1.
DR CDD; cd01684; Tet_like_IV; 1.
DR CDD; cd04168; TetM_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR035650; Tet_C.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43261:SF1; RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43261; TRANSLATION ELONGATION FACTOR G-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR PRINTS; PR01037; TCRTETOQM.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}.
FT DOMAIN 1..242
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 639 AA; 72354 MW; DB446D1AF93D8F58 CRC64;
MKIINIGILA HVDAGKTTLT ESLLYTSGAI AEQGNVDKGT TRTDTMILER QRGITIQTAV
TSFCWNDYKI NIVDTPGHMD FLTEAYRSLS VLDGAVLVIS AKDGVQAQTR ILFHALQKMD
IPTIIFINKI DQNGIDLRRV YQSIKDKLTS DMIVMQEVSL SPKITMTDIS DLDKWDMIIS
GSDELLERYV AEDSLDIQEL QYEKCKRTRC CSLFPVYHGS AKDNLGTEKL IEAITETFIT
ETDDIQSELC GYVFKVEYTE RKKRLSYLRL YHGTLHLRDT LLLSKKEKIK ITEMCIPSNG
EIVPVDHACP GEIVILADDT LKLNDILGNE KLLPHKTRID NPMPLLRTTV EPQKPEQREA
LLNALTEIAD TDPLLHFDID TVTHEIILSF LGKVQLEVIC SLLEEKYHVG VAMKEPSVIY
LERPQKKASY TIHIEVPPNP FWASIGLTVT PLPVGSGTQY KSEVSLGYLN QSFQNAVMEG
VRYGMEQGLY GWGVTDCQIC FDYGVYYSPV STPADFRFLA PVVLEQALKK AGTQLLEPYL
SFTLFAPQEY LSRAYNDAPK YCAIIESTRL EKDEVIFKGE IPARCIGEYR NDLNFYTNGR
SVCITELKGY QETSGEPVFQ PRRPNSRLDK IRHMFQKIM
//
