ID J8PKM5_SACAR Unreviewed; 1010 AA.
AC J8PKM5;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=Origin recognition complex subunit 1 {ECO:0000256|RuleBase:RU365058};
GN ORFNames=SU7_2403 {ECO:0000313|EMBL:EJS42640.1};
OS Saccharomyces arboricola (strain H-6 / AS 2.3317 / CBS 10644) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=1160507 {ECO:0000313|EMBL:EJS42640.1, ECO:0000313|Proteomes:UP000006968};
RN [1] {ECO:0000313|EMBL:EJS42640.1, ECO:0000313|Proteomes:UP000006968}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H-6 / AS 2.3317 / CBS 10644
RC {ECO:0000313|Proteomes:UP000006968};
RX PubMed=23368932; DOI=10.1186/1471-2164-14-69;
RA Liti G., Nguyen Ba A.N., Blythe M., Mueller C.A., Bergstroem A.,
RA Cubillos F.A., Dafhnis-Calas F., Khoshraftar S., Malla S., Mehta N.,
RA Siow C.C., Warringer J., Moses A.M., Louis E.J., Nieduszynski C.A.;
RT "High quality de novo sequencing and assembly of the Saccharomyces
RT arboricolus genome.";
RL BMC Genomics 14:69-69(2013).
CC -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC origins of replication. DNA-binding is ATP-dependent, however specific
CC DNA sequences that define origins of replication have not been
CC identified so far. ORC is required to assemble the pre-replication
CC complex necessary to initiate DNA replication.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBUNIT: ORC is composed of six subunits.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU365058}.
CC -!- SIMILARITY: Belongs to the ORC1 family.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJS42640.1}.
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DR EMBL; ALIE01000145; EJS42640.1; -; Genomic_DNA.
DR AlphaFoldDB; J8PKM5; -.
DR HOGENOM; CLU_012774_1_1_1; -.
DR OrthoDB; 2040079at2759; -.
DR Proteomes; UP000006968; Chromosome XII.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0032993; C:protein-DNA complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04720; BAH_Orc1p_Yeast; 1.
DR Gene3D; 1.10.10.2450; -; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 2.30.30.490; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR041083; AAA_lid_10.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1.
DR PANTHER; PTHR10763:SF23; ORIGIN RECOGNITION COMPLEX SUBUNIT 1; 1.
DR Pfam; PF17872; AAA_lid_10; 1.
DR Pfam; PF01426; BAH; 1.
DR SMART; SM00439; BAH; 1.
DR SUPFAM; SSF82061; BAH domain; 1.
DR PROSITE; PS51038; BAH; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU365058};
KW DNA replication {ECO:0000256|RuleBase:RU365058};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU365058};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU365058};
KW Nucleus {ECO:0000256|RuleBase:RU365058};
KW Reference proteome {ECO:0000313|Proteomes:UP000006968}.
FT DOMAIN 48..188
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT REGION 235..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..263
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..476
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1010 AA; 116031 MW; 47D80EC25ACBCE89 CRC64;
MAKALKDLDG WQLVITDDKG RIIDENNRRR SRKRGVENVF LKRNSDGLRF GKGESVIFND
VVTETYSVYL IHEIRLNTLN NLVEIWVFSY LRWFELKPKL YYEQFKPDII KEDHPMEFYK
ERFFNEVNKS ELYLTAELSE VWLKDFIAVG QILPESKWHD DGTEKVENRD FLVRYACEPT
AERFVPIDIF QIIKRVKEME PKQSDEYLKR ISVPASANKI NRHVVHKLGL ESSAKRQQRL
TKKLPMKEIK VEPSSDDDLK MNLTSEGETP SGNDLHPTQS KDILRNTTSA SALPSTTDTA
RIVQRRPISK ELIISEEIPM NSSEQESDDD SLTEQNSKNL KEISLFPRKP IPLTSNGFVG
PDDHHDNFVK THGAVKMHGG SEIELSTSES SSEAIFMANK RRRTYGDNTG RKAQKFHIEG
TQEDSENDDI ESSQSQAIVG NEIRDNVKQN DRLTLSKPED KKEINEKTKI PKGQGKDKNG
KNQLVFTGEK SKIIDFSALS KLKRKYQKIL DHYAPGNQIM DLSQFKEVRE TQPDMDVADL
EDKLRRAKAK PEKDTILSKL NGKADLKELV RESLRKRKSP SSQVEDFVKI FLPIYDSLMS
SRNKLFYVVN ENEPAKSRLV REVMDELVTS SNHKELPIFD YIFTDALEFT DIKIFFERVW
TFISGETLSG DISLEALNFY FTKVSKSKKR RTLILVQNVD HLLNKETLQC FEKWISSKNS
KLSIIGIGGD NAVIKEQINM LPSFKSHFSE IVLDSITKDD LQEMVISHIT SSLKPFYVKV
NDKNEMALYN NIREEQKQRL PENVISINHK INKKIIKLIA KNMANVSNDT EKAFKICDMA
VEISKNDFVK KGGLQKDKPV VSQEILPRYF SEAISGSEDE TVAKKIIGMS LLMRVFLYTL
ARGIEGSNHN TLALDIILTK IVQMLQDNPA YRATESIKRV TCGIWEPQIT IEKLKQFSWI
GIINELAKEK LIVVVLEEPS ASIRVELTLS HLDVEYAFSM DEDFKNVDKV
//
