ID J9ESM5_WUCBA Unreviewed; 1218 AA.
AC J9ESM5;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
GN ORFNames=WUBG_03901 {ECO:0000313|EMBL:EJW85188.1};
OS Wuchereria bancrofti.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX NCBI_TaxID=6293 {ECO:0000313|EMBL:EJW85188.1, ECO:0000313|Proteomes:UP000004810};
RN [1] {ECO:0000313|Proteomes:UP000004810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NA {ECO:0000313|Proteomes:UP000004810};
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Hepburn T.,
RA Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M.,
RA Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "The Genome Sequence of Wuchereria bancrofti.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001436,
CC ECO:0000256|RuleBase:RU003431};
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJW85188.1}.
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DR EMBL; ADBV01001271; EJW85188.1; -; Genomic_DNA.
DR AlphaFoldDB; J9ESM5; -.
DR Proteomes; UP000004810; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431}; Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000313|EMBL:EJW85188.1};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Transferase {ECO:0000313|EMBL:EJW85188.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 564..869
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 941..1072
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 878..909
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1218 AA; 139227 MW; 146BC9392BD66060 CRC64;
MNGILNNSKL MLEKAADEKL NSDRSILISY LAAISQFPKN LFDSLKLLSE ANNIETTAER
DKNYGYLSKC FRTDFEGSMI SGALQVAVDD VNADPELLPN HKLVLDFFMQ HWAQGAKVFI
GPEMNCRTEA TMAAAQNLPI LSYKCKDEMM SDKSKYPTFA RTVPTETEIT AALIALFKHF
EWRKFSVIYE RNVANEELFR SIKSTIEKQN VDLEVSDTQY VIINVSIVPH PFSEIERSNI
KQIISDTYAS TRIYLTFGNV RLFRRILLEM GAQGLMESGD YALIYLDPDY NWLNTYHAMN
NHFFRDTLLS VKQSWNDLNS QDRKVVNFSK FALAIIPTPV QLNAPEFIAF WRKANHYLSL
FGVKQSNTAT SIKANRFACY LYDAVKLYAS ALTIVLNETA NEQLSVGYDP ISDGKRIIGH
ILGRVYRSIQ GFDMHINSNG DAQGNYTLLS LQEIEPVLDM DNPDYYPLNY GLDISADFVH
DFTGDLPLLR FKRDIQWPTG FAPRDEPICG FHGKMCKKGT FFNIHLIIHL VLLRYILDRY
FRLVVNSFPD SSHCILSYKF EKELSNVWKI DQREIEKIVQ CCESAASLYV VENNQILLQN
DEECNQEKRW PGLCGVALYK GAVVSIDEIT YPRKVKELTR AAKLEMRIMR QLHHDNINSF
RGIVIGSSSI CVVREFCARS SLMDILRNHD LKLDHLFIAS FVEDLVKGMI YLHESDLGVH
GNLKSTNCLI TSRWTLQIAD FGLHEIRDGQ EWESDDFMWE NFLWTSPELL RKSGCVHAVK
GTQKGDAYSF GIILHEIITR QGPFMMLRNS DLTAEEVVLN VLNNVDYRPS CDGLPAASYV
INVMTLSWSA IPANRPDFRT IRHKLKPMLE PIYKRNIMDH MMVMMEKYQN QLEDLVDERT
TELREEKRRT ENLLQRMLPV SVAQQLLAGL DVVPESFSSV TIYFSDIVDF TKISGISTPL
QVVEFLNKLY TLFDHIIKQY DVYKVETIGD AYMVVSGMPE ARPVEVHAEQ IGMMALHLLA
AVRNFKIPHL PQEQLRLRIG IHTGPCVAGV VGKTMPRYCL FGDTVNTASR MESNGCPLKI
HCSEQTQDVL ARIDGFELKK RGTLQIKGKG LMTTYWLTSR RNVTFAIKDE CELLLDEKLA
QNIFPRMSVR HRRLSTSAIS KGSSISLAGK EPSLLRRIIE RATFLRNDNL EFCSGYIHES
SSVNSNRPQM TCSILPYR
//
