ID J9EV40_WUCBA Unreviewed; 1221 AA.
AC J9EV40;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Homeobox protein cut-like {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=WUBG_03061 {ECO:0000313|EMBL:EJW86028.1};
OS Wuchereria bancrofti.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX NCBI_TaxID=6293 {ECO:0000313|EMBL:EJW86028.1, ECO:0000313|Proteomes:UP000004810};
RN [1] {ECO:0000313|Proteomes:UP000004810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NA {ECO:0000313|Proteomes:UP000004810};
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Hepburn T.,
RA Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M.,
RA Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "The Genome Sequence of Wuchereria bancrofti.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the CUT homeobox family.
CC {ECO:0000256|ARBA:ARBA00008190}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJW86028.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADBV01000898; EJW86028.1; -; Genomic_DNA.
DR AlphaFoldDB; J9EV40; -.
DR Proteomes; UP000004810; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 3.
DR InterPro; IPR003350; CUT_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR PANTHER; PTHR14043; CCAAT DISPLACEMENT PROTEIN-RELATED; 1.
DR PANTHER; PTHR14043:SF2; HOMEOBOX PROTEIN CUT; 1.
DR Pfam; PF02376; CUT; 3.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM01109; CUT; 3.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 3.
DR PROSITE; PS51042; CUT; 3.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}.
FT DOMAIN 517..607
FT /note="CUT"
FT /evidence="ECO:0000259|PROSITE:PS51042"
FT DOMAIN 800..887
FT /note="CUT"
FT /evidence="ECO:0000259|PROSITE:PS51042"
FT DOMAIN 945..1032
FT /note="CUT"
FT /evidence="ECO:0000259|PROSITE:PS51042"
FT DOMAIN 1077..1137
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 1079..1138
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 672..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1137..1163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 98..149
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 219..324
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 749..779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1137..1162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EJW86028.1"
SQ SEQUENCE 1221 AA; 137413 MW; B7F66B9314CE994C CRC64;
RNLNEEVQAV GVRESQCRVA RQQLIAESKN YYEHADKQSR KAASPLIRAF QKEYDRAIER
AKAAEADLIF VCRTFTAVCD PSPYLEQVST LLKEVVRLRS VEEQVRDLTK QLNELQEEYN
HLRNQDLTIR QLKERMKEME AKTNSSIQTA INEREKGLRV ELEAFEREVA ERRVQSTAEN
KVLSDAVADL AMKNKETNRI FEETKLQSVK NEGVDDEKLG IVTNDLENAL QRAVEAEKKV
QRLQGELERF SRAGSNPNEG AFGGTSLTHS KDSQIRKLLE ENKKLNSKLI HLKTESNKRI
DELTQELERH VEIVAQLRAQ LEAQSDYEDN EKGLRNLRNV ELGEETAERT CFVSNGVTAT
ATATAEVQLG GRSKALDELL IGKNRKSHSE NADLQMRNQK FEGDHHSVLE EQAMDGNDLS
DVFGLVDANF NSNTLADLFS SKSGQKSIQT NGDLNLESDP HRATSLLNLF MCSASSSSDT
PKLENYYSTT SSNLHELPRS PAELRTYNEL QDIVTRNIHE LGTKALNTTE IAKQCKHLMV
THNIGQRLFA KYVMNQVVKS QGSLSELLSK PRHWNKLTDK GREAFRRMYG WVSDPKAIEL
LCNISPRRTQ PVGSLNELFF ILYMSGLIEI EVPSREILWD QQAVSLAAVS RYNADDTFDL
FVQKQSSKVT PGDLKQRDKL SAAAGGGGAN SVVQRTSRWR HDDIPKEKIM KIYKRELALL
REQESHLEQA IGSRPLSVRS KDEKLPTVET SNKSSSLSSS SSRCGSTRDT NSPPQSNFPV
NSAQALFALK CRSGMASITQ EELERYPVLD TEDIVRQIKD FLCLNSISQR QFGEHVLGLS
QGSVSDLLAR PKPWAMLTQK GREPFVRMQL FLNEAQSLVC KPEEELNGKL GALQSLEVLP
RNERNNGAKQ DSISGLLSMR SFPSGDEIDH EIVKCRTEKV REIKKLSVMD DGDKKVVRSL
KKELLMADTS EIARQTFGDV ILGVSPGGVS ELLTKPKTWE QLSPRARDLY LKMNEWLSEL
DGNTRIQETS TSTALLSSSL TATFSSMVDA LTSTGALTKT LSPQKRKATL NAAAGELPKK
AQRTVITDQQ KEALKHVFER DQHPNQRTIE QLSQTLSLST RTVSNWFHNY RTRQKASLRA
ENLPNGDNGQ KRNSANGKNN SDRWKQDLAE LMKLESKPYH WSPTMVSPGS NSNLTRSTIT
KNSSLDKAIE RIQKLNASKQ L
//
