ID J9FIZ4_9SPIT Unreviewed; 3271 AA.
AC J9FIZ4;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 13-SEP-2023, entry version 45.
DE SubName: Full=Inositol 1,4,5-triphosphate receptor {ECO:0000313|EMBL:EJY78106.1};
GN ORFNames=OXYTRI_24742 {ECO:0000313|EMBL:EJY78106.1};
OS Oxytricha trifallax.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC Stichotrichia; Sporadotrichida; Oxytrichidae; Oxytrichinae; Oxytricha.
OX NCBI_TaxID=1172189 {ECO:0000313|EMBL:EJY78106.1};
RN [1] {ECO:0000313|EMBL:EJY78106.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JRB310 {ECO:0000313|EMBL:EJY78106.1};
RX PubMed=23382650; DOI=10.1371/journal.pbio.1001473;
RA Swart E.C., Bracht J.R., Magrini V., Minx P., Chen X., Zhou Y.,
RA Khurana J.S., Goldman A.D., Nowacki M., Schotanus K., Jung S., Fulton R.S.,
RA Ly A., McGrath S., Haub K., Wiggins J.L., Storton D., Matese J.C.,
RA Parsons L., Chang W.J., Bowen M.S., Stover N.A., Jones T.A., Eddy S.R.,
RA Herrick G.A., Doak T.G., Wilson R.K., Mardis E.R., Landweber L.F.;
RT "The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome
RT with 16,000 Tiny Chromosomes.";
RL PLoS Biol. 11:E1001473-E1001473(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJY78106.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMCR01009897; EJY78106.1; -; Genomic_DNA.
DR EnsemblProtists; EJY78106; EJY78106; OXYTRI_24742.
DR OrthoDB; 179557at2759; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0006816; P:calcium ion transport; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.80.10.50; -; 2.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR PANTHER; PTHR13715:SF99; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR13715; RYANODINE RECEPTOR AND IP3 RECEPTOR; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR SMART; SM00472; MIR; 2.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50919; MIR; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:EJY78106.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3014..3039
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3060..3082
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3146..3169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 561..608
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 267..313
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 495..526
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2675..2702
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3271 AA; 384674 MW; 545B2377D65389C5 CRC64;
MASSGIITGT GNRSNQLQSY DSRRGDLPPK ATRPGQQSVV GIRNNREDTQ QDMRIDDSRY
YNIQGGNNFS RDESPMTKNY RANQQNSIQE ESGQLGSQYR RGGGVTSHSI LRKSNINEYS
VDNNQSMGGA GSRMKHTTAQ SGTIIQQNNK NVSRITSQDQ TRMNERDRKG FLRVGDIISI
QYNEKVYDGD TKSKKKQDGE VQNINLAKIT DKPKMIYKGV INSNGVTNKS FNVIPKQIYL
PFNGSSQFQR CLFRIELAQE CKYSIIHQQL EVELVELERD LDDAEEEEKE PLIEKIEEAK
TKIKENQKFL TEENRNNEYE LKMNLGQKMS YGQKIQFKHL FSQQYLTLNQ NKITPEHGCV
GLNLSGLNDN SYFTLVPSQK IKFNGQSISY QDTFYIQNYI INIVKQPRFY VHVNSLEIED
SGDMAVLEIN ASHEPSRLKA RLFMDHNYLF QDKTCLQSGD PIRLFHKEVN GYLTVNPKEV
EIMLPQYPDF LQRQIKQLNQ AGANRNDQLQ QQKDEDNDIN QVQQEDEKKL LKTKIYIERD
PDCLFETDSY WEIQKVKPFK GGSILWDDIY RIRHIGTGRY LCVSPEKLEL TLKIEADDYD
TLFRIRRQSF SPFQSANYEE LKSGENIVIE NFFQKYIQIY QDFNDDEMEK FQYKVKSLYH
KYSQESTESQ IPTVCGFFSK DDVSKMIFEI QEVPKLKAMI AYQAYNFFES FKDFYGFLNY
WAVLPCDEDE DAFEKFKYDP QNAVLSEYQL MQNVEDFLTC LLYLDRLLHK AIDENKQSYI
QTQNFLSEQG ILSILVKLLE LIYYKTVPFE EREQPFLSAK NKGMRKIKMD DNDAELIARE
YLDPLAEKIM KSIFLLLRFN ELNANIMTRY DGIIYNMLQR YDVKIVSKIF KETFKRATYI
HNDRSAAIMN EEGLNLRVIS QMQDTAVGNH FNQTFGNQIN KWAEMIETVS YMDERDQNIN
KQILYLKVIG LMCCDVTGKA LYHYQMQAVF NLISNEQNVP IRFSIQKKDV DRIYVSFIKK
NKENTEIFFL KNPNLREIFK QNTSAYAKDF EISFDLAEIT QKWEFTMPYI DYICTVLDLY
TRMCMGRNVE AVKKVRELGL SPDLILNGMT SKVIHERFKA AFVNIARVLY VDCDPFPSLN
HSKNRCYFWD VVGKAHAHKT MYGWEKQKYE NVHQNKIISN AQEQIRETAE KIRYFVNQFF
QTGPSDIIEF LYSYATKTYT KGDIDPKLKL FINNVEIATS LIECEHVDSR FIYRMIKTAS
LLFLSYNIVD VPEEGESSWI VRFMKVSKQH RACTNKIELL EQKVLKLLQT VCKYRLGFQV
MVFLKLFKKS QEDNDLPNIF IDQTDIDQKF NIIFSLYQFS VDKNATSKML EELKFLFRET
KVNKNNAKNM TLLDIEDIQL SDIAEEVQDD PTMKNLKKKQ MTMLPDNDLT EEEREKLEAK
KKKRLKNKKY ALYEFLIYLT LSKNQSNQLI KREAVDLLVE NFKQRHNLLQ ELIKVELLIS
FQDKQEYQDF KFQTFRLSEH IDQLSHDDLY YLLYMNIDKE KYKKCVSDVI NILRGLSQSL
KGNQQRLFKK QNMLRHLDVQ QDLLGKLMKN LYFKPVDHFE LYNEISNFLF MYSYENPNNQ
KTLLGHLNFL CDLLDKNIPN TKLISQVISH HKRTQEGSLF LEFLLQKLVR QNFFKSYILK
LLVIMTQDSP SNQVVILKRL IKKKRFRKRL YLDSLNNGKK VELVSNFKKK IHLFQQRNAL
KNDVDWERIN LHLSTIDLLA ACSRNSLYGI LQARKLIEVE ALFDSILHES VPYLFKKHYF
RLLFEIYIND VADVSNMDLN SQKFVQVLMF VVLDDLKQYP YFYTGLVTKL MADAKRDNEN
EKNRESNLQS LEKMSKIQVQ RMSQERTALE IENYKESKQR ASGLRTNQSK PYPLINDSDF
QEYWKYLSQF QKSLNQADGL LHFIRDFYRN IRKIKFKMNQ EIVDITARIK DVLINMSDDL
HSIYEKTKEN LIDIDQIIFH INEAIASIPS SKKPKQGIID NQEENQEDDE AQMLSDESNM
VQDLDDSKML DIRMASDKIL RIVRDHIISK NCQIKEAFDI ESISNDEYIS KFQLKKKLKD
IAGMEASFAE IDKAISFFVD FSREQQQERK IMQVEIGQEG HIHSRNAPNP DSDLTFNFRD
FEILLKKILQ KAGYKPPHQK RDRQVEEQLL FKMTEEELSQ ACNNDMKLYS KSFFDFCMKY
VHQDELKDLI LKISKIFNKA FEKNQTETIK EYVENMIEGF QNGQQNLFLI RILKMILEQY
TPQNFDEDTE KEVLIVAKKR LNQLQIIFKD CKVCELILKN ISKTEKHDVS HECVLLLNAL
LCQSDGVIQD ELLKLLKGSQ QHYMFFEYIQ NRLQLSSEKL IKESEIKLIQ QTVGEEMEKK
KPGIKTLPKQ MQKYGNLGNP QQNEVVLTNI NQQPFYMSQR FDLESELEKL QKQSMTNELM
HLLKLVFEHV EQIFISLISL LNGPCPQNQK LLGFWKNFCR SINYFFSQDL GYYSANTTEQ
KSKLILILQS SRLLTAMIES SSEQFQRDQL KEITQEVKMS VLKSKMVEIF QFKIGGDDKK
LHVYMADLKC RHYLKHGIVR GNTCEKDEYC QYGHLIYYDE QTIQAGFNIF NFFLKFYEIL
PDSLEIKGCD FDMKNDDFYH EFKDIYMLKL KRKSYVSKSN NSQRIEEDKQ KLEADRRQKA
EDLLQQMALL EPSKKMFPEK EDPKQKKQQA MLEQGIDAEK STGGKIVNQY GELVDDDSAY
EDQIVLRSQT TRFGKKKEGK CRRKQNRLRQ NKVMISGTLG DVDQNDELLT SDGNGALNKN
YVGDRQAKKL IKEHEEIKNL KLSMKSQYKL EPVYSFEQFK LDTAIRFYIS NVSNVEVNFN
GQLSKVMFQV PSFCKVSSKT ISELIEVLAI VQMVLAISIM ISYFQRFHGV FYQKYQESLK
NLRSISLTDF KGTIGFSKSF EPFKDPDQQQ ISLKPENKST LQTRINLGKQ FLDSLKYIFH
TFYLGLLMDI KQQYYFVHMI LSIVGLFYFP IFSFLLLEIV IKVPILTKVI QSLLVNWKQI
VYTFLLVVVF VYIYAIIAIQ AFRDDFYDES ATDQENPMFN GYCESLIMCF TTTLNNGLRA
SGGIGDTLEQ LNDRDKLYWG RWFFDITFFL IIIILLLNLV LGIIIDAFAE LREQNKLLNS
DMRDKCFICG LTKSDFEKRN KSFKMHILRE HNIYSYLYFM LYLQHKEESE CSGVERYVKN
QIQNKGTIFF PINRCTLFED GTTGNNYQQQ H
//
