ID   J9H8W5_9ZZZZ            Unreviewed;       625 AA.
AC   J9H8W5;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   08-NOV-2023, entry version 31.
DE   SubName: Full=DNA mismatch repair protein mutl {ECO:0000313|EMBL:EJX10910.1};
GN   ORFNames=EVA_00415 {ECO:0000313|EMBL:EJX10910.1};
OS   gut metagenome.
OC   unclassified sequences; metagenomes; organismal metagenomes.
OX   NCBI_TaxID=749906 {ECO:0000313|EMBL:EJX10910.1};
RN   [1] {ECO:0000313|EMBL:EJX10910.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23251564; DOI=10.1371/journal.pone.0051521;
RA   Alcaide M., Messina E., Richter M., Bargiela R., Peplies J., Huws S.A.,
RA   Newbold C.J., Golyshin P.N., Simon M.A., Lopez G., Yakimov M.M., Ferrer M.;
RT   "Gene sets for utilization of primary and secondary nutrition supplies in
RT   the distal gut of endangered iberian lynx.";
RL   PLoS ONE 7:E51521-E51521(2012).
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJX10910.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AMCI01000010; EJX10910.1; -; Genomic_DNA.
DR   AlphaFoldDB; J9H8W5; -.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd00782; MutL_Trans; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR   Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204}.
FT   DOMAIN          209..327
FT                   /note="DNA mismatch repair protein S5"
FT                   /evidence="ECO:0000259|SMART:SM01340"
FT   DOMAIN          443..584
FT                   /note="MutL C-terminal dimerisation"
FT                   /evidence="ECO:0000259|SMART:SM00853"
SQ   SEQUENCE   625 AA;  69489 MW;  152C4D9CC2D4F48A CRC64;
     MSDIIHLLPD SVANQIAAGE VIQRPASVIK ELVENAIDAE AENVHVLVTD AGKTCIQVID
     DGKGMSETDA RLSFERHATS KIREAGDLFA LRTMGFRGEA LASIAAVAQV ELKTRLESEE
     LGTKLLIAGS KLESQEVVSC SKGSNFSVKN LFFNVPARRK FLKANSTELS NILAEFERIA
     LVHPEVAFSL YSNDSELFNL PVAPLRQRIM AIFGKKLNQQ LLNVEVNTTM VKVTGYVAKP
     ETARKKGAHQ FFFVNGRYMR HPYFHKAVME AYEHLIPAGE QISYFIYFEV DPASIDVNIH
     PTKTEIKFEN EQAIWQILSA SVKESLGKFS AIPSIDFDTE DMPDIPAFEP EVLPEPPRVH
     YNSDYDPFKV SGTSYGRPKG EWEDLYSGLT KPSKINASEA ELEQGWEEPF LKTEEQSQEA
     TLESVASSPL YVDEGILEKG NKYLQFKGRF ILTSVKSGLM LIDQHRAHIR VLYDRYMVQI
     QQKQGVSQGV LFPEILQLPA SEATVLQNIM EDLISVGFDL SDLGGGSYAI NGIPAGIEGL
     NPVELVRNML HTAMEKGKDV KDEIHSILAL TLSRAAAIVY GQVLNDEEMS HLVDALFACA
     APNYTPDGKV ILSMIKEDDI ERLFR
//