ID J9HXG5_9SPIT Unreviewed; 1261 AA.
AC J9HXG5;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Cyclic nucleotide-binding domain-containing protein {ECO:0000259|PROSITE:PS50042};
GN ORFNames=OXYTRI_14712 {ECO:0000313|EMBL:EJY65138.1};
OS Oxytricha trifallax.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC Stichotrichia; Sporadotrichida; Oxytrichidae; Oxytrichinae; Oxytricha.
OX NCBI_TaxID=1172189 {ECO:0000313|EMBL:EJY65138.1};
RN [1] {ECO:0000313|EMBL:EJY65138.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JRB310 {ECO:0000313|EMBL:EJY65138.1};
RX PubMed=23382650; DOI=10.1371/journal.pbio.1001473;
RA Swart E.C., Bracht J.R., Magrini V., Minx P., Chen X., Zhou Y.,
RA Khurana J.S., Goldman A.D., Nowacki M., Schotanus K., Jung S., Fulton R.S.,
RA Ly A., McGrath S., Haub K., Wiggins J.L., Storton D., Matese J.C.,
RA Parsons L., Chang W.J., Bowen M.S., Stover N.A., Jones T.A., Eddy S.R.,
RA Herrick G.A., Doak T.G., Wilson R.K., Mardis E.R., Landweber L.F.;
RT "The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome
RT with 16,000 Tiny Chromosomes.";
RL PLoS Biol. 11:E1001473-E1001473(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJY65138.1}.
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DR EMBL; AMCR01021656; EJY65138.1; -; Genomic_DNA.
DR AlphaFoldDB; J9HXG5; -.
DR EnsemblProtists; EJY65138; EJY65138; OXYTRI_14712.
DR OrthoDB; 52684at2759; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR10217:SF435; POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG; 1.
DR PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 568..669
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 166..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1032..1055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1261 AA; 146690 MW; 4E80D0DC7747D001 CRC64;
MFGSKKNLSF YQSNNHLGAN LITPTARKKI GSIISNKTVK DLLMKHQMGG GGIGTPGLKF
MNQQRKLSNI QDSYMNQNSI AGMSQSDFDY TQGMMTVRHK NNVVNHQDFG SSYAYSQEPG
GMYDSPALHE MNQFDNSRHE NNMMNRATAL NNNREQITRN VSELKKIKKK KKNQKRQDSF
RSRKSSTTVL HRNRKSKGGL SRITNILRNV TFKKDFETTS NGSDTDQEEE DPMQILIAIL
VPFNMSFGLQ DFPISALILL EIIMIFDIFV IMNCGYYTKG MLIMQRNLII KRYLRSWFIL
DFLAAIPAYS IYRQILKENI LMSSDQLLTG NHLQEIQKNK VEFSYYRSQV LSFLFLQFMK
VLKIIKFTDL QSRVYDFIMT EVGEIFFKAF KLSFLIFMVA HWLGCFFWLI GGTQDHISAE
TWIRPYLDLS LDEQYVNSIY WAITTMVTVG YGDIHPTNTY ERLATIVNML VASGMYAYII
NEVATMVRLY NTLATKYEES MKYVNKFMKQ KGIPEDLRTK IVRYLEYNWE QKKKIKIEER
EVYGLLNENL RDKITLYLNG KILRNIQIFE SFSIEFISRL TFVFKKQSFA VDEIIFNEDT
IGQDMFFISS GKVYIIHKKT MSFVKELYKD DHFGEIGFFS DLPRQATIKA RDYTDTMILS
KENFLKVAGD DFLALKLKGN LIPLIVKSEI QKFREEQNQN IFQMLTKSKN QKKPKNNANR
FFQKRVQGNG TSPKGDKFEN SQRGLLKDIK DQNKNQEFEH LTEDKGDNFH QQSNSFDFNN
EDKLREHIQM QLLRKNQEYN KVPHNSIKES LDSEYQISSD SQSRNIKKTT NSLDFNYEIQ
ANLLDRQRVN AIRIEQLSQA NSFQFISQGT FINNNSGDEL NQYTAKNQPF KRRTHKISFN
NDISQNQIIE ENSSSSSSIG AQKRIIAKSK KVLKTVTQKF SSLRNDRVPI DDLLRMSGEV
IPQQQKNRDL DSPFKKIISP KKPSKIEKLV ESSLETENMD GIENFEMEID KLLLNDLKNE
EQIMNEINML TTPKKTPQKK NEDQVSGLQN SNQREIISPL LRNNLTNNRP QTEDRINEQV
LQQNEPKIAK NYTRLLREKT RTTEVNLQQM QTKSKNIHRN IKKRPKASRI QQKDLFSNKF
FVEDFLEDIN SATILESENL NQIETPKSGL KYAKYNSTNM YQQPLAFKRT LSNKGNIGVN
PFNFINQSRT SHNQNLKVNI SRFGLGDSSP LNSSIENLNQ IDDQNETDSQ DELMKSIEKA
Y
//
