ID   J9IQZ7_9SPIT            Unreviewed;       349 AA.
AC   J9IQZ7;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=NAD-dependent epimerase/dehydratase {ECO:0000313|EMBL:EJY84262.1};
GN   ORFNames=OXYTRI_17998 {ECO:0000313|EMBL:EJY84262.1};
OS   Oxytricha trifallax.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC   Stichotrichia; Sporadotrichida; Oxytrichidae; Oxytrichinae; Oxytricha.
OX   NCBI_TaxID=1172189 {ECO:0000313|EMBL:EJY84262.1};
RN   [1] {ECO:0000313|EMBL:EJY84262.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JRB310 {ECO:0000313|EMBL:EJY84262.1};
RX   PubMed=23382650; DOI=10.1371/journal.pbio.1001473;
RA   Swart E.C., Bracht J.R., Magrini V., Minx P., Chen X., Zhou Y.,
RA   Khurana J.S., Goldman A.D., Nowacki M., Schotanus K., Jung S., Fulton R.S.,
RA   Ly A., McGrath S., Haub K., Wiggins J.L., Storton D., Matese J.C.,
RA   Parsons L., Chang W.J., Bowen M.S., Stover N.A., Jones T.A., Eddy S.R.,
RA   Herrick G.A., Doak T.G., Wilson R.K., Mardis E.R., Landweber L.F.;
RT   "The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome
RT   with 16,000 Tiny Chromosomes.";
RL   PLoS Biol. 11:E1001473-E1001473(2013).
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. Dihydroflavonol-4-reductase subfamily.
CC       {ECO:0000256|ARBA:ARBA00023445}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJY84262.1}.
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DR   EMBL; AMCR01004199; EJY84262.1; -; Genomic_DNA.
DR   AlphaFoldDB; J9IQZ7; -.
DR   EnsemblProtists; EJY84262; EJY84262; OXYTRI_17998.
DR   OrthoDB; 1694166at2759; -.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd05227; AR_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR10366:SF564; 3BETA_HSD DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          8..248
FT                   /note="NAD-dependent epimerase/dehydratase"
FT                   /evidence="ECO:0000259|Pfam:PF01370"
SQ   SEQUENCE   349 AA;  39204 MW;  B4DDD422433EBC56 CRC64;
     MERSQNLVVI TGISGYLGSQ VCKLFLEDGS FRVRGTVRDK TNEKKVAPLR KAFGALFEKL
     ELVEADLTNA QSLENAIEGV DFVVHTASPF PDSSPKDENV LIRPAVDGTL AVVRAAHKNR
     VKRVVITSSV AAIMMQTEKT SKEQYTEEDW SNLEGIQPYE KSKTLAERAA WDFVNGLPDD
     EKFELVTINP SLILGPAIVQ SDFTSGQVIR KLLNGDFPGV PRINFPLVDV RDVALAHLRA
     ITVPEARNNR FILNCQGMWF KDIAETLKAE YGKYYKVKTG ELKYCTIKFV ALFDKQAKMI
     LPFWNKALNL DNRKSREILG IQYQNTRDTI VGMADSMIDS GLIKDKRKK
//