ID J9K8T8_ACYPI Unreviewed; 1486 AA.
AC J9K8T8;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Tyrosine-protein kinase receptor {ECO:0000256|RuleBase:RU000312};
DE EC=2.7.10.1 {ECO:0000256|RuleBase:RU000312};
GN Name=100168659 {ECO:0000313|EnsemblMetazoa:XP_016662253.1};
GN Synonyms=InR {ECO:0000313|EMBL:QFO38043.1};
OS Acyrthosiphon pisum (Pea aphid).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Aphidomorpha;
OC Aphidoidea; Aphididae; Macrosiphini; Acyrthosiphon.
OX NCBI_TaxID=7029 {ECO:0000313|EnsemblMetazoa:XP_016662253.1, ECO:0000313|Proteomes:UP000007819};
RN [1] {ECO:0000313|Proteomes:UP000007819}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LSR1 {ECO:0000313|Proteomes:UP000007819};
RA Jiang H., Abraham K., Ali S., Alsbrooks S.L., Anim B.N., Anosike U.S.,
RA Attaway T., Bandaranaike D.P., Battles P.K., Bell S.N., Bell A.V.,
RA Beltran B., Bickham C., Bustamante Y., Caleb T., Canada A., Cardenas V.,
RA Carter K., Chacko J., Chandrabose M.N., Chavez D., Chavez A., Chen L.,
RA Chu H.-S., Claassen K.J., Cockrell R., Collins M., Cooper J.A., Cree A.,
RA Curry S.M., Da Y., Dao M.D., Das B., Davila M.-L., Davy-Carroll L.,
RA Denson S., Dinh H., Ebong V.E., Edwards J.R., Egan A., El-Daye J.,
RA Escobedo L., Fernandez S., Fernando P.R., Flagg N., Forbes L.D.,
RA Fowler R.G., Fu Q., Gabisi R.A., Ganer J., Garbino Pronczuk A.,
RA Garcia R.M., Garner T., Garrett T.E., Gonzalez D.A., Hamid H.,
RA Hawkins E.S., Hirani K., Hogues M.E., Hollins B., Hsiao C.-H., Jabil R.,
RA James M.L., Jhangiani S.N., Johnson B., Johnson Q., Joshi V., Kalu J.B.,
RA Kam C., Kashfia A., Keebler J., Kisamo H., Kovar C.L., Lago L.A.,
RA Lai C.-Y., Laidlaw J., Lara F., Le T.-K., Lee S.L., Legall F.H.,
RA Lemon S.J., Lewis L.R., Li B., Liu Y., Liu Y.-S., Lopez J., Lozado R.J.,
RA Lu J., Madu R.C., Maheshwari M., Maheshwari R., Malloy K., Martinez E.,
RA Mathew T., Mercado I.C., Mercado C., Meyer B., Montgomery K., Morgan M.B.,
RA Munidasa M., Nazareth L.V., Nelson J., Ng B.M., Nguyen N.B., Nguyen P.Q.,
RA Nguyen T., Obregon M., Okwuonu G.O., Onwere C.G., Orozco G., Parra A.,
RA Patel S., Patil S., Perez A., Perez Y., Pham C., Primus E.L., Pu L.-L.,
RA Puazo M., Qin X., Quiroz J.B., Reese J., Richards S., Rives C.M.,
RA Robberts R., Ruiz S.J., Ruiz M.J., Santibanez J., Schneider B.W.,
RA Sisson I., Smith M., Sodergren E., Song X.-Z., Song B.B., Summersgill H.,
RA Thelus R., Thornton R.D., Trejos Z.Y., Usmani K., Vattathil S.,
RA Villasana D., Walker D.L., Wang S., Wang K., White C.S., Williams A.C.,
RA Williamson J., Wilson K., Woghiren I.O., Woodworth J.R., Worley K.C.,
RA Wright R.A., Wu W., Young L., Zhang L., Zhang J., Zhu Y., Muzny D.M.,
RA Weinstock G., Gibbs R.A.;
RL Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:QFO38043.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GR {ECO:0000313|EMBL:QFO38044.1}, and LSR1
RC {ECO:0000313|EMBL:QFO38043.1};
RA Barbera M., Canas-Canas R., Martinez-Torres D.;
RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:XP_016662253.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2022) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171,
CC ECO:0000256|RuleBase:RU000312};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. Insulin receptor subfamily.
CC {ECO:0000256|RuleBase:RU000312}.
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DR EMBL; MK510960; QFO38043.1; -; mRNA.
DR EMBL; MK510961; QFO38044.1; -; mRNA.
DR RefSeq; XP_008185917.1; XM_008187695.2.
DR RefSeq; XP_016662252.1; XM_016806763.1.
DR RefSeq; XP_016662253.1; XM_016806764.1.
DR STRING; 7029.J9K8T8; -.
DR EnsemblMetazoa; XM_008187695.3; XP_008185917.1; LOC100168659.
DR EnsemblMetazoa; XM_016806763.2; XP_016662252.1; LOC100168659.
DR EnsemblMetazoa; XM_016806764.2; XP_016662253.1; LOC100168659.
DR EnsemblMetazoa; XM_029490471.1; XP_029346331.1; LOC100168659.
DR GeneID; 100168659; -.
DR KEGG; api:100168659; -.
DR eggNOG; KOG4258; Eukaryota.
DR HOGENOM; CLU_000288_166_0_1; -.
DR InParanoid; J9K8T8; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000007819; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0022008; P:neurogenesis; IEA:UniProt.
DR GO; GO:0000003; P:reproduction; IEA:UniProt.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd00064; FU; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR PANTHER; PTHR24416:SF525; INSULIN-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00261; FU; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU000312};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000312};
KW Reference proteome {ECO:0000313|Proteomes:UP000007819};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000312};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1040..1062
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 584..698
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 702..798
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 935..1032
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1100..1379
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 1132
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1486 AA; 169314 MW; 2E8E93CB7E1DA17B CRC64;
MCGECDKIRC LRDSCPGLGG CRLCGNFSSN IYYEHYNFLR PSSSAKFSKV NPKHYRKPWL
IATKSVWKSD FLCIALWCVA ILSVSQASAE HQTQITSLPP IVAQPTNNSG VHFSAGRICQ
SKDIRNKAEN LNALRGCRVI EGFLQIVLID NANETSYESL SFPELREITG YLLLYRVNGL
KSLAKLFPNL SVIRGQDLFM SYAIAIYEMV HLQELGLYNL MDVVRGAVYI TKNPMLCFTQ
TIDWIRIAPS GKESHDIYDN RPVNACPVCP WTNDISCSVS NHTNEPLCWN TEHCQRICPP
ECGNLSCTDD GTCCHEQCLG GCTGKNHDDC FACKYLADER DCVKECPAET LTYQNRRCIL
ERDCYRMPRS RDLQNGLHLQ SWKPFNNKSC VMECPPGFEE VPTENSYGKV FKCQQCSGPC
RKVCIAANVE SIQSAQKLKG CVIINGSLEI QIRGGMNIVK ELEESLSMIE EITGYLKVVR
SFPLVSLTFL RKLHVIRGET LESSKYALVV LDNQNLVELW DWSTRKPDGE LRIERGQIFF
HFNPKLCIYR IKQLQTNLGD RFKNVDDLEV APNSNGDKMA CTVKKLNVST EVVLSNSVLL
KWSPFEHYDT RTLLGYVVYY LEAPYKNVSL YDGRDACGGD GWKTDDVEST EATTYDLVAL
ITGLKPYTQY AYYVKTYTMA SESNGAQSDI DYFRTMPGTP SPPQNLRVKS VTADSINIEW
MPPAEPNGEL KHYIIKYTSI NISGDSLLKR DYCQNSPNVN EFPDSYSGSL NEMVNNDKKE
NCNCTDQPEK KQSKIKDEQQ IQIMIEFENN LQNILYVKTN PKSDTSPKKK RDVSNFDLQE
FPNSTIRINL LSDADKNLEN ENKKIVVPSN QLTFTLHENL THFTSYNIEL YVCREWLTNE
IKEPNQNISN CSIQKAMTTA QTSKKESADR IDQLTVKAVN ANTTSPGSIK IFWKEPEVSN
GPIVSYQLEY KKVGDHLNPP VVCITRQQYQ QSDYSHTLSN VAPGNYSFRL RARSLADYGE
FTQYSYFLIP EALSITTPQL MFIIFMVTGM IGAVIMLIFY VLHRYYKNKL ASTRLFVTCN
PDYVSCEYQT DEWEIPRDDV EVLEPLGRGS FGMVYRGNWK KKENEIVPCA IKTVTENNNM
MVRHDFLSEA NVMKEFCSAH VVRLYGVVSQ GQPAFVLMEL MPQGDLKSYL LKHRPEMTTD
PSLKPPTLRD NLRMAIEIAD GMSYLSFKKY VHRDLAARNC MVSDNNIVKI GDFGLTRDIY
QTDYYRKDSE GMMPIRWMAP ESLQSGLFTC FSDVWSYGIV LWEMVTLAAQ PYRGEIDKNV
ISYVSSGGIM EKPDNCPDII YDCMKLCWRF KASERPTFAE IVKMFLPCAR ADFAQTSFFH
NELQSETQRL DVSENGITET ESLERERKQT ERDQITTALE NQAHYWGGSL PVERLAPKAD
LEEDDDDDED SDNELQRLHI ENFACKRPPN GYMSIHNGNG INTTIC
//
