ID J9PVX3_OSMMO Unreviewed; 743 AA.
AC J9PVX3;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=ARHGAP22-like protein {ECO:0000313|EMBL:AEZ68571.1};
OS Osmerus mordax (Rainbow smelt) (Atherina mordax).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Stomiati; Osmeriformes; Osmeridae;
OC Osmerus.
OX NCBI_TaxID=8014 {ECO:0000313|EMBL:AEZ68571.1};
RN [1] {ECO:0000313|EMBL:AEZ68571.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23009612; DOI=10.1186/1471-2148-12-190;
RA Graham L.A., Li J., Davidson W.S., Davies P.L.;
RT "Smelt was the likely beneficiary of an antifreeze gene laterally
RT transferred between fishes.";
RL BMC Evol. Biol. 12:190-190(2012).
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DR EMBL; JQ514278; AEZ68571.1; -; Genomic_DNA.
DR AlphaFoldDB; J9PVX3; -.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04390; RhoGAP_ARHGAP22_24_25; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228:SF22; RHO GTPASE-ACTIVATING PROTEIN 22; 1.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT DOMAIN 40..149
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 159..353
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 654..730
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 499..513
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..605
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 743 AA; 81390 MW; 9C24A410CD30C957 CRC64;
MTAMLSPKIR QTRRARSKSM VMGEVSRGPC RPSSPGVQEG ALKAGWLKKQ RSIMKNWQLR
WFVLRSDQLY FYKDEEETKP QGCIPLQGCQ VNELTANPDE PGRHLFEIVP GGTGGEKDRA
GVSHEAFLLM ANSQTDMDDW VKAIRRVIWA PFGGGIFGQR LEDTVQYEKK FGPRLAPLLV
EQCVDFIRER GLDEEGLFRM PGQANLVKEL QEAFDCGDKP LFDSNTDVHT VASLLKLYLR
ELPEPVVPFA KYEDFLSCAQ LLAKDEEEGV QELGKQVSTL PLANYNLLKY ICKFLDEVQS
HASENKMGVQ NLATVFGPNI LRPKMEDPVA IMEGTSLVQH LMTSLIRDHK RLYSGRDQEV
PQLDATLPGQ QLQHRNLGAW ISEEDLHSCP TSHPDQDLHS SSASSLDAKL CAAVTPSPNP
NPTPRLGKGE TLVSPSKQAK TLPSWKYSFK GSSAPRTQAQ AKQIVVVVGS STADVSSVTS
GGGGGNWLMN GLSSLRGHRR TSSGERARDR DSTGSSQRLS TYDNVTSSSS MGSVPSVAST
PWSTSSCEIS VPDSGGSESA GQHCGGVGEK EDWQELGSPH GQRGRDRGEG GGRGEVGAER
GSEDSCEAME LCVSSAGCSD DGNSVAAVPT IVMSEDGDGD GGPRALSCLV EGLQEELSKQ
KTAYESRIKK LEDSSMALCA QMERLEQEME QERKKQRMLE IKLRNSERAR QDAENRNRLL
EKEMEDFFST LGDLALGART SDI
//