ID J9S6Q9_9ACTN Unreviewed; 422 AA.
AC J9S6Q9;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=3-oxoacyl-(Acyl-carrier-protein) synthase / malonyl-ACP decarboxylase {ECO:0000313|EMBL:AFR49751.1};
GN ORFNames=KTR9_3116 {ECO:0000313|EMBL:AFR49751.1};
OS Gordonia sp. KTR9.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC Gordonia.
OX NCBI_TaxID=337191 {ECO:0000313|EMBL:AFR49751.1, ECO:0000313|Proteomes:UP000003281};
RN [1] {ECO:0000313|EMBL:AFR49751.1, ECO:0000313|Proteomes:UP000003281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KTR9 {ECO:0000313|EMBL:AFR49751.1,
RC ECO:0000313|Proteomes:UP000003281};
RX PubMed=22923396; DOI=10.1128/AEM.02120-12;
RA Chen H.P., Zhu S.H., Casabon I., Hallam S.J., Crocker F.H., Mohn W.W.,
RA Indest K.J., Eltis L.D.;
RT "Genomic and transcriptomic studies of an RDX (hexahydro-1,3,5-
RT trinitro-1,3,5-triazine)-degrading actinobacterium.";
RL Appl. Environ. Microbiol. 78:7798-7800(2012).
CC -!- PATHWAY: Lipid metabolism; mycolic acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004796}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
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DR EMBL; CP002907; AFR49751.1; -; Genomic_DNA.
DR RefSeq; WP_010841191.1; NC_018581.1.
DR AlphaFoldDB; J9S6Q9; -.
DR STRING; 337191.KTR9_3116; -.
DR KEGG; gor:KTR9_3116; -.
DR PATRIC; fig|337191.3.peg.3467; -.
DR eggNOG; COG0304; Bacteria.
DR HOGENOM; CLU_000022_69_2_11; -.
DR UniPathway; UPA00915; -.
DR Proteomes; UP000003281; Chromosome.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProt.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF336; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022516};
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 16..421
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 422 AA; 44226 MW; 2E8BDE2577C8C61E CRC64;
MTPSSLREYS TLGGNFPSVV VTSMVATTSL GGDLDSTWKN LLAGESGIRE LTDDFITKYN
LPVRIGGRLL QDPAEEVTRV ESRRMAYVER IAHVMSKRLW AQAGEPDVDK DRLAVVIGTG
QGGADAMVDA VQAMETTGNY RKVSPLAVSM AMPNGPAAVA GLNVGARAGV ITPVSACSSG
AEAIAHAWRH IVMGDADMVV TGGVEGHIDA VPIAAFSMMR AMSTRNDDPA AASRPFDKDR
DGFVFGEGSA MLILEREDHA RARGAHIHAR LLGSGITSDG FHLVAPDPSG QGNARAMTRA
LQTAGLQRSD ITHINAHATS TPIGDTAEAA GILAAIGQHA AVYAPKSALG HSIGAVGALE
SVLTIKSVEE GVIPPTLNLE NLDPECDIDV VHGEPRYGQI EYAINNSFGF GGHNVALAFG
RY
//
