ID J9VLL9_CRYNH Unreviewed; 714 AA.
AC J9VLL9;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Glycosyl hydrolase {ECO:0000313|EMBL:AFR94341.2};
GN ORFNames=CNAG_05077 {ECO:0000313|EMBL:AFR94341.2};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR94341.2, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR94341.2, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
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DR EMBL; CP003823; AFR94341.2; -; Genomic_DNA.
DR RefSeq; XP_012048488.1; XM_012193098.1.
DR AlphaFoldDB; J9VLL9; -.
DR GeneID; 23888427; -.
DR KEGG; cng:CNAG_05077; -.
DR VEuPathDB; FungiDB:CNAG_05077; -.
DR HOGENOM; CLU_010399_2_0_1; -.
DR OrthoDB; 1428525at2759; -.
DR Proteomes; UP000010091; Chromosome 4.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR011613; GH15-like.
DR InterPro; IPR045582; Trehalase-like_N.
DR PANTHER; PTHR31616:SF0; GLUCAN 1,4-ALPHA-GLUCOSIDASE; 1.
DR PANTHER; PTHR31616; TREHALASE; 1.
DR Pfam; PF00723; Glyco_hydro_15; 1.
DR Pfam; PF19291; TREH_N; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:AFR94341.2}.
FT DOMAIN 28..194
FT /note="Trehalase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF19291"
FT DOMAIN 321..698
FT /note="GH15-like"
FT /evidence="ECO:0000259|Pfam:PF00723"
SQ SEQUENCE 714 AA; 79826 MW; 77D1552AF446BCEB CRC64;
MQSPTNENKM VEPTDIPKKS LDKLGLPVRS IQDHALIGNL RTAAIVSMDG SIESMCIPYF
DSPSVFARIV DADKGGHFSI APTWPFKPKQ AYAPNSNVLV TKFLSERGVG VMTDLLVPKG
ANINNSSSRA FLPWLIRKVE SIRGKVPFKM ECAPAFNYCR DKHTAEIVPD DSSSNVISQD
TKVLFKSPSL TLDLRTITWS SDQCVSDPEI KLRVEDVSER GLLGPAATCD FELEEGQCVV
FVMREVGDYS YANEEHQEFA NPTTSKAKSM GVPVEQMLEA TNRLRPKENP ILTRSLVAAL
IRDTTSYWKK WIGGIKYSGR WRQAMLRSAL TLKMLVFEET GAIVAAPTFS LPEFIGGQRN
WDYRFTWVRD SSFTLYALIR LGFTEEADAF VNFILERLKD RNSDGSLQIV YTIHGGKDLE
EIELSHLAGH KGSKPVRIGN GAADHLQLDI YGELLDCIYL AQKYSKPLGW DSWVAVRQVV
DYVCGQVDNP DLSIWEVRGQ QKNFTYSKIM MWVAIDRGIR LADKRCLPCP NRSKWLETRD
RLYETIQHRA WNPSKQIFAQ SYEDLNTLDS AVLIMPLVFF ISAADPRFTN TLDAILKTPE
KGGLTANNSV YRYNAQLSDD GIGGEEGAFS LCTLWCVEAL TRAGVYNAKY LDYAVNMFMD
FLGYGNHVEL YSEEISPGGE GLGNTPQAFS HVTLISAGFN LDRALSGSGR SAWA
//
