ID J9VRG6_CRYNH Unreviewed; 925 AA.
AC J9VRG6;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 22-FEB-2023, entry version 49.
DE SubName: Full=NAD kinase {ECO:0000313|EMBL:AFR97047.2};
GN ORFNames=CNAG_04316 {ECO:0000313|EMBL:AFR97047.2};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR97047.2, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR97047.2, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
CC -!- SIMILARITY: Belongs to the NAD kinase family.
CC {ECO:0000256|ARBA:ARBA00010995}.
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DR EMBL; CP003828; AFR97047.2; -; Genomic_DNA.
DR RefSeq; XP_012051490.1; XM_012196100.1.
DR AlphaFoldDB; J9VRG6; -.
DR GeneID; 23887751; -.
DR KEGG; cng:CNAG_04316; -.
DR VEuPathDB; FungiDB:CNAG_04316; -.
DR HOGENOM; CLU_008831_6_2_1; -.
DR OrthoDB; 455155at2759; -.
DR Proteomes; UP000010091; Chromosome 9.
DR GO; GO:0003951; F:NAD+ kinase activity; IEA:InterPro.
DR GO; GO:0019674; P:NAD metabolic process; IEA:InterPro.
DR GO; GO:0006741; P:NADP biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR HAMAP; MF_00361; NAD_kinase; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR017437; ATP-NAD_kinase_PpnK-typ_C.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR InterPro; IPR002504; NADK.
DR PANTHER; PTHR20275; NAD KINASE; 1.
DR PANTHER; PTHR20275:SF0; NAD KINASE; 1.
DR Pfam; PF01513; NAD_kinase; 1.
DR Pfam; PF20143; NAD_kinase_C; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AFR97047.2};
KW NAD {ECO:0000256|ARBA:ARBA00023027}; NADP {ECO:0000256|ARBA:ARBA00022857};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REGION 1..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 703..764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 806..899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..721
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..738
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 744..760
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..869
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 870..889
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 925 AA; 102184 MW; 3F17438716EDFC22 CRC64;
MPDTRPSTPP PSSSVRGSRA PQPSPYLNVP TTARMRHPAA PSPLSKCDPT LENPRSISAM
SSPDHTSLAA PSTSALAVPE ASPCFIHSHL DRHGSLQDWL KNKSANNRTH FVPDSPTSSK
ARSNHGQHHH TNTNEPVLQS DVPFPSHNNQ GNISSPPSAS QPSSPRDNAS HVSLSRKGPP
FNGYESDQSS VNEYGTRTPN LLNGLIGDGL LEGDDEGNGS LTKQLAETAQ GVREMSKELG
RTKVRSRIQN VLIVTKARDN RLIKLTRELA LYLMQKRPTA SPDGSSSRHG NGSRDRGLVV
YVDAQLQTSK RFDAAGLQRE YPHLFVPMAR QRSSSSASVN TLSHISAFSS TTSMGEAAKQ
ATNGEGQLRY WTSELCSATP HLFDFVITLG GDGTVLFTSW LFQRIVPPVL PFALGSLGFL
TNFDFYKYKE TIDKVVDEGI RVNLRMRFTC TVYRAVASGD IAVSKSKKRK AIKKPGGEIL
MSRVDKGGWE SLEGPTPAVS PSEFEGEDKE IMCYSTRPVE QFEVLNDLVV DRGPSPYVSL
LELFGDEHHL TTVQADGLTV STPTGSTAYS LSAGGSLAHP QIPAILITPI CPHTLSFRPM
LLPDSMELRV CVPYNSRSTA WASFDGRGRV ELKQGDHIKV TASKYPFPTV CADKASTDWF
SSISRTLRWN EREKQKSFVV VEEASDPPER SGDRKEDAKK DLFEEGRAKQ KFEKDAKASG
DLVESEDEED DEEEIFDIDD KSGPSSPPVQ QQQQPTKNEM FPHQLHYLLS SHQNGLETPN
RFVTPYSAPP ALSQRHLVEA IHKAEIHEKE KEKGQRDSIG ENPAPLRVDK SRHPSQLGRT
VSQSTEEAEA ERVEREEKLR KEETPKHGQQ QRHHHHHHHH HHHHGHKPKR TPSNLAEKVA
DCKAKAFAFF GQDDDSASDC SGSEE
//
