ID J9VT98_CRYNH Unreviewed; 489 AA.
AC J9VT98;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=sphingolipid C(9)-methyltransferase {ECO:0000256|ARBA:ARBA00039020};
DE EC=2.1.1.317 {ECO:0000256|ARBA:ARBA00039020};
GN ORFNames=CNAG_01475 {ECO:0000313|EMBL:AFR97682.1};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR97682.1, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR97682.1, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
CC -!- SIMILARITY: Belongs to the CFA/CMAS family.
CC {ECO:0000256|ARBA:ARBA00010815}.
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DR EMBL; CP003830; AFR97682.1; -; Genomic_DNA.
DR RefSeq; XP_012052547.1; XM_012197157.1.
DR AlphaFoldDB; J9VT98; -.
DR SwissPalm; J9VT98; -.
DR GeneID; 23885181; -.
DR KEGG; cng:CNAG_01475; -.
DR VEuPathDB; FungiDB:CNAG_01475; -.
DR HOGENOM; CLU_026434_5_0_1; -.
DR OrthoDB; 5484439at2759; -.
DR Proteomes; UP000010091; Chromosome 11.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR45197:SF1; SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED; 1.
DR PANTHER; PTHR45197; SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED; 1.
DR Pfam; PF02353; CMAS; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Methyltransferase {ECO:0000313|EMBL:AFR97682.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AFR97682.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 59..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 489 AA; 56611 MW; BF1B46ECB536B53F CRC64;
MAEEKQPIGF RTTSYPTIAN PPLPAEGCAS FSNYELAASI IFGPWIIQRL LPLPNGWKTY
WFLVVLLGVP IAVAYWTLKS KFGKRVNEKV RLPGKPISHY LDFKDKELEE KYKDRKIPMQ
IFHDAYFDKK VDFKGDVLDV MEYRHDWATF EFTPELFKYV FTKLIPDVIF HSQAQDEDQV
RDHYDRGDDF YSWFLGPRMI YTGGVMTDIS RQETLEELQD NKLRLVCEKL DLKEGDHMLD
IGCGWGTLAA FAGKNYNVDV TGVTLARNQA AFGTQRLREN GVPEERGRIL CMDYRDIPQA
PGYYNKITCL EMAEHVGIRR YGKFLKEVYD LLADDGVMVF QVAGIRTCWQ FEDLVWGLFM
NKYVFPGADA SCALNWVVSQ LEHANFEIKS IDVLGVHYSA TLHRWYQNWL SNKDKCVAKY
GERWYRIWAF FLAYSVISSR QGSASVFQIT CHKNLNGFHR VEGVPSHTSL HAPVSRKLEP
VVSHNEMWE
//
